LMTK2 Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: LMTK2 Antibody [NBP1-89320] - Staining of human cell line A-431 shows localization to nuclear speckles & microtubule organizing center.

Immunohistochemistry-Paraffin: LMTK2 Antibody [NBP1-89320] - Staining of human colon shows cytoplasmic positivity in glandular cells.

• Reactivity: Hu
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

LMTK2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: MELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENV
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LMTK2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  LMTK2 Protein (NBP1-89320PEP)

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 26008968).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for LMTK2 Antibody - BSA Free

• AATK2
• AATYK2FLJ46659
• Apoptosis-associated tyrosine kinase 2
• Brain-enriched kinase
• BREK
• BREKCDK5/p35-regulated kinase
• CPRK
• EC 2.7.11
• KIAA1079hBREK
• kinase phosphatase inhibitor 2
• Kinase/phosphatase/inhibitor 2
• KPI-2
• KPI2EC 2.7.11.1
• lemur tyrosine kinase 2Serine/threonine-protein kinase KPI-2
• LMR2
• LMR2cyclin-dependent kinase 5/p35-regulated kinase
• LMTK2
• serine/threonine-protein kinase LMTK2

Background

The protein encoded by the LMTK2 gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LMTK2 Antibody (NBP1-89320)(1)

Publication using NBP1-89320

• Shah K, Bradbury NA. Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy. Oncotarget 2015-06-10 [PMID: 26008968] (ICC/IF, Human)

Bioinformatics

• Gene Symbol: LMTK2