LMTK2 Products

Description

The protein encoded by the LMTK2 gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. (provided by RefSeq)

Bioinformatics

Entrez	22853 Human 231876 Mouse 304286 Rat
Uniprot	NP_055731 Human NP_055731.2 Human Q8IWU2 Human
Product By Gene ID	22853
Alternate Names	AATYK2FLJ46659 Apoptosis-associated tyrosine kinase 2 Brain-enriched kinase BREKCDK5/p35-regulated kinase CPRK cprk EC 2.7.11 KIAA1079hBREK kinase phosphatase inhibitor 2 Kinase/phosphatase/inhibitor 2 KPI-2 KPI2EC 2.7.11.1 lemur tyrosine kinase 2Serine/threonine-protein kinase KPI-2 LMR2cyclin-dependent kinase 5/p35-regulated kinase serine/threonine-protein kinase LMTK2

Research Areas for LMTK2

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Protein Kinase