AATK/Serine/threonine-protein kinase LMTK1 Antibody (456006) [Unconjugated]

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A172 human glioblastoma cell line was stained with Mouse Anti-Human AATK Monoclonal Antibody (Catalog # MAB4866, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications CyTOF-ready, Flow
Clone
456006
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

AATK/Serine/threonine-protein kinase LMTK1 Antibody (456006) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human AATK
Asn421-Ala589
Accession # AAH47378
Specificity
Detects human AATK in direct ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
AATK
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for AATK/Serine/threonine-protein kinase LMTK1 Antibody (456006) [Unconjugated]

  • AATK
  • AATYK
  • AATYKp35-binding protein
  • apoptosis-associated tyrosine kinaseCDK5-binding protein
  • Brain apoptosis-associated tyrosine kinase
  • EC 2.7.11
  • KIAA0641p35BP
  • Lemur tyrosine kinase 1
  • LMR1
  • LMR1EC 2.7.11.1
  • LMTK1
  • LMTK1AATYK1
  • p35BP
  • serine/threonine-protein kinase LMTK1

Background

Apoptosis-associated tyrosine kinase (AATK) is a 155 kDa membrane-associated intracellular protein that promotes neurite extension and neuronal differentiation. Low extracellular potassium levels induce AATK phosphorylation and apoptosis in cerebellar granule cells. AATK negatively regulates the Na-K-2Cl cotransporter by promoting its PP1-dependent dephosphorylation. The two alternate splice forms of AATK also contain the sequences included in this immunogen. Within this region, human AATK shares 63% aa sequence identity with mouse AATK.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for AATK/Serine/threonine-protein kinase LMTK1 Antibody (MAB4866) (0)

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FAQs for AATK/Serine/threonine-protein kinase LMTK1 Antibody (MAB4866) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol AATK
Uniprot