LIGHT/TNFSF14 Antibody (261639) [DyLight 680]

• Reactivity: Mu
• Applications: WB
• Clone: 261639
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 680

LIGHT/TNFSF14 Antibody (261639) [DyLight 680] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse LIGHT
  Asp72-Val239
  Accession # Q9QYH9
• Specificity: Detects mouse LIGHT in direct ELISAs and Western blots. In Western blots, this antibody shows less than 10% cross-reactivity with recombinant mouse (rm) EDA, rmTRAIL, rmTRANCE, rmTWEAK, and rhVEGI but does not cross-react rm4-1BB Ligand, rhAPRIL, rmBAFF, rhEDA-A2, rmFas Ligand, rhGITR Ligand, rmGITR Ligand, rhLymphotoxin alpha ₁/ beta ₂, rhLymphotoxin alpha ₂/ beta ₂, rmOX40 Ligand, and rmTNF-alpha .
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: TNFSF14
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product MAB1794. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for LIGHT/TNFSF14 Antibody (261639) [DyLight 680]

• CD258 antigen
• CD258
• delta transmembrane LIGHT
• Herpes virus entry mediator ligand
• Herpesvirus entry mediator ligand
• HVEM-L
• HVEMLherpesvirus entry mediator-ligand
• ligand for herpesvirus entry mediator
• LIGHT
• LIGHTherpesvirus entry mediator A
• LTg
• TNFSF14
• TR2
• tumor necrosis factor (ligand) superfamily, member 14
• tumor necrosis factor ligand superfamily member 14
• tumor necrosis factor receptor-like 2
• tumor necrosis factor superfamily member LIGHT

Background

TNFSF14 is encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFSF14