LDLR Antibody (C7) [Allophycocyanin]

• Reactivity: Hu, Rt, Po, Bv
• Applications: WB, ELISA, Flow, Func, ICC/IF, IHC, IP, MS
• Clone: C7
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

LDLR Antibody (C7) [Allophycocyanin] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Partially purified bovine LDL receptor [Swiss-Prot# P01131].
• Localization: Cell membrane/cell surface, endomembrane system, endosomes, lysosome, clathrin-coated pit, and Golgi apparatus
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: LDLR
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Electron Microscopy
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • In vitro assay
  • Proximity Ligation Assay
  • Radioimmunoassay
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-78159. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for LDLR Antibody (C7) [Allophycocyanin]

• FH
• FHC
• LDL R
• LDL receptor
• LDLCQ2
• LDLR
• low density lipoprotein receptor
• low-density lipoprotein receptor class A domain-containing protein 3
• low-density lipoprotein receptor

Background

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis. Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits. It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) were shown to be mediated by LDL receptors on cultured cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LDLR Antibody (NBP1-78159APC)(1)

Publication using NBP1-78159APC

• Konečná K, Přerovská T, Loja T et al. Functional characterization of 16 variants found in the LDL receptor gene Journal of Lipid Research 2025-09-01 [PMID: 40769381]

Bioinformatics

• Gene Symbol: LDLR