LDLR Products

Description

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis. Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits. It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) were shown to be mediated by LDL receptors on cultured cells.

Bioinformatics

Entrez	16835 Mouse 281276 Bovine 300438 Rat 3949 Human
Uniprot	AAH14514 Human AAH14514.1 Human NM_000527 Human NP_000518 Human P01130 Human P01130 Human P01131 Bovine
Product By Gene ID	3949
Alternate Names	FH FHC LDL receptor LDLCQ2 low density lipoprotein receptor low-density lipoprotein receptor class A domain-containing protein 3 low-density lipoprotein receptor

Research Areas for LDLR

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Lipid and Metabolism
Signal Transduction