Latent TGF-beta bp2/LTBP-2 Antibody - BSA Free

Staining of human cell line U-2 OS shows localization to nucleus.

Staining of human cerebral cortex shows no positivity in neurons as expected.

Staining of human skin shows no positivity in squamous epithelial cells as expected.

Staining of human placenta shows moderate positivity in extracellular space in trophoblastic cells.

Staining of human lung shows strong positivity in extracellular space in pneumocytes.

• Reactivity: Hu
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Latent TGF-beta bp2/LTBP-2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: ERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERG
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LTBP2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  Latent TGF-beta bp2/LTBP-2 Recombinant Protein Antigen (NBP1-88411PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Latent TGF-beta bp2/LTBP-2 Antibody - BSA Free

• C14orf141
• GLC3D
• Latent TGFbeta bp2
• Latent TGF-beta bp2
• latent transforming growth factor beta binding protein 2
• latent-transforming growth factor beta-binding protein 2
• LTBP2
• LTBP-2
• LTBP3chromosome 14 open reading frame 141
• MSTP031

Background

LTBP2, also known as latent-transforming growth factor beta-binding protein 2, is a 195 kDa, 1,821 amino acid protein that is involved in assembly and organization of cellular structure as a member of the latent transforming growth factor=beta binding protein (LTBP) family. Current research is being conducted to study the effect of the protein on diseases and disorders such as fibrosis, primary congenital glaucoma type 3D, carcinoma, hepatitis, melanoma, corneal edema, Weill-Marchesani Syndrome, and pancreatitis. The protein interacts in elastic fiber formation, paxillin interaction, mitochondrial apoptosis, extracellular matrix organization, and molecular mechanisms of cancer pathways with other proteins including FYN, FBLN5, and ABL1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Latent TGF-beta bp2/LTBP-2 Antibody (NBP1-88411)(1)

Publication using NBP1-88411

• De Maria A, Zientek KD, David LL et al. Compositional Analysis of Extracellular Aggregates in the Eyes of Patients With Exfoliation Syndrome and Exfoliation Glaucoma Investigative Opthalmology & Visual Science 2021-12-29 [PMID: 34964803] (Immunocytochemistry/ Immunofluorescence)

Bioinformatics

• Gene Symbol: LTBP2