Latent TGF-beta bp4 Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

Latent TGF-beta bp4 Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Latent TGF‑ beta bp4 isoform 1
Ser25-Ala1666 (Arg542-Pro547)
Accession # AAI41006
Specificity
Detects mouse Latent TGF‑ beta bp4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) LTBP-1 and rhLTBP-2 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
LTBP4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF2885 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Latent TGF-beta bp4 Antibody

  • Latent TGFbeta bp4
  • Latent TGF-beta bp4
  • latent transforming growth factor beta binding protein 4
  • LTBP4
  • LTBP-4
  • LTBP4L
  • LTBP4S

Background

LTBP-4 is a 170 kDa extracellular glycoprotein that belongs to the LTBP/fibrillin family. These proteins contain a conserved pattern of eight cysteine residues (8Cys) and EGF-like domains. Mouse LTBP-4 isoform 1 is synthesized as 1666 amino acid residues and contains 14 EGF-like motifs and three 8Cys, the 3rd of which is responsible for disulfide-association with the latency-linked associated peptide (LAP) of latent TGF-beta 1. LTBP-4 is expressed in multiple tissues and is involved in the assembly, secretion and targeting of latent TGF-beta to sites where it can be activated. Two additional splice isoforms that differ from isoform 1 in residues 60‑150 or 67‑150, have been described. Human and mouse LTBP-4 share 90% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Latent TGF-beta bp4 Antibody (AF2885)(5)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC, IHC, Western Blot.


Filter By Application
ICC
(2)
IHC
(1)
Western Blot
(2)
All Applications
Filter By Species
Mouse
(5)
All Species
Showing Publications 1 - 5 of 5.
Publications using AF2885 Applications Species
A Schiavinat, DR Keene, T Imhof, R Doliana, T Sasaki, G Sengle Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts Sci Rep, 2017;7(1):5526. 2017 [PMID: 28717224] (ICC, Mouse) ICC Mouse
Y Fujikawa, H Yoshida, T Inoue, T Ohbayashi, K Noda, H von Melchn, T Iwasaka, I Shiojima, TO Akama, T Nakamura Latent TGF-? binding protein 2 and 4 have essential overlapping functions in microfibril development Sci Rep, 2017;7(0):43714. 2017 [PMID: 28252045] (ICC, Mouse) ICC Mouse
Bultmann-Mellin I, Conradi A, Maul A, Dinger K, Wempe F, Wohl A, Imhof T, Wunderlich F, Bunck A, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Dis Model Mech, 0;8(4):403-15. 0 [PMID: 25713297] (Western Blot, Mouse) Western Blot Mouse
Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama T, Kusumoto K, Zilberberg L, Sakai L, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin D, Nakamura T Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc Natl Acad Sci U S A, 2013;110(8):2852-7. 2013 [PMID: 23382201] (IHC, Mouse) IHC Mouse
Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J. Exp. Med., 2009;206(4):819-31. 2009 [PMID: 19332876] (Western Blot, Mouse) Western Blot Mouse

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Bioinformatics

Gene Symbol LTBP4
Uniprot