Latent TGF-beta bp1 Antibody (35409)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, AP
Clone
35409
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Latent TGF-beta bp1 Antibody (35409) Summary

Immunogen
Human platelet-derived large latent TGF-beta 1 complex
Specificity
Detects human LTBP-1 from the large latent TGF-beta 1 complex.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LTBP1
Purity
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunoaffinity Purification
Publications
Read Publications using
MAB388 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Latent TGF-beta bp1 Antibody (35409)

  • Latent TGFbeta bp1
  • Latent TGF-beta bp1
  • latent transforming growth factor beta binding protein 1
  • latent-transforming growth factor beta-binding protein 1
  • LTBP1
  • LTBP-1
  • MGC163161
  • TGF-beta1-BP-1
  • Transforming growth factor beta-1-binding protein 1

Background

TGF-beta  is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-beta 1 complex is composed of three components: mature TGF-beta 1 dimer; latency associated peptide; and a latent TGF-beta binding protein (LTBP) (1-3).The cDNAs for four binding proteins (LTBP-1, -2, -3 and -4) have now been cloned (4-5).
  1. Miyazono, K. et al. (1991) EMBO J. 10:1091.
  2. Moren, A. et al. (1994) J. Biol. Chem. 269:32469.
  3. Yin, W. et al. (1995) J. Biol. Chem. 270:10147.
  4. Kanzaki, T. et al. (1990) Cell 61:1051.
  5. Saharinen, J. et al. (1998) J. Biol. Chem. 273:18459.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Latent TGF-beta bp1 Antibody (MAB388)(9)

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 5 applications: ICC, IHC, IHC-Fr, Immunoprecipitation, Western Blot.


Filter By Application
ICC
(2)
IHC
(1)
IHC-Fr
(1)
Immunoprecipitation
(1)
Western Blot
(4)
All Applications
Filter By Species
Human
(8)
Primate - Macaca mulatta (Rhesus Macaque)
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using MAB388 Applications Species
AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Sci Rep, 2018;8(1):603. 2018 [PMID: 29330377] (ICC, Human) ICC Human
ATRA modulates mechanical activation of TGF-? by pancreatic stellate cells Sci Rep, 2016;6(0):27639. 2016 [PMID: 27375161] (IHC, Human) IHC Human
Brophy T, Coller B, Ahamed J Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor beta1 (TGF-beta1) activation. J Biol Chem, 2013;288(15):10628-39. 2013 [PMID: 23463512] (Western Blot, Human) Western Blot Human
Willet J, Pichitsiri W, Jenkinson S, Brain J, Wood K, Alhasan A, Spielhofer J, Robertson H, Ali S, Kirby J Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-beta. J Leukoc Biol, 2013;93(4):471-8. 2013 [PMID: 23192429] (ICC, Human) ICC Human
Shen M, Siu S, Byrd S, Edelmann KH, Patel N, Ketchem RR, Mehlin C, Arnett HA, Hasegawa H Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31. Exp. Cell Res., 2011;317(7):976-93. 2011 [PMID: 21182835] (Western Blot, Human) Western Blot Human
Massam-Wu T, Chiu M, Choudhury R Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J. Cell. Sci., 2010;123(0):3006-18. 2010 [PMID: 20699357] (Immunoprecipitation, Human) Immunoprecipitation Human
Vehvilainen P, Hyytiainen M, Keski-Oja J Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1. J. Cell. Physiol., 2009;221(3):586-93. 2009 [PMID: 19681046] (Western Blot, Human) Western Blot Human
Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J. Pathol., 2009;218(1):131-42. 2009 [PMID: 19224541] (IHC-Fr, Human) IHC-Fr Human
Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 2004;172(9):5753-64. 2004 [PMID: 15100322] (Western Blot, Primate - Macaca mulatta (Rhesus Macaque)) Western Blot Primate - Macaca mulatta (Rhesus Macaque)

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Bioinformatics

Gene Symbol LTBP1