LAT Antibody

Images

 
Western Blot: LAT Antibody [NBP2-27104] - analysis of LAT in mouse thymus tissue lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Goat anti-rabbit Ig HRP secondary antibody and ...read more
Immunohistochemistry-Paraffin: LAT Antibody [NBP2-27104] - FFPE human small intestine stained with LAT antibody at 10 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, PmSpecies Glossary
Applications WB, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

LAT Antibody Summary

Immunogen
A portion of amino acid 70-120 of human LAT was used as the immunogen. 86 cQPLGGSHRTPSSRRDS 101
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LAT
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/mL
  • Immunohistochemistry-Paraffin

Reactivity Notes

The amino acid sequence used as immunogen for the LAT antibody is 88% homologous in new world monkey, 82% homologous in rat, rabbit, dog and pig, and 75% homologous in mouse and cow.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for LAT Antibody

  • 36 kDa phospho-tyrosine adapter protein
  • LAT
  • LAT1,36 kDa phospho-tyrosine adaptor protein
  • linker for activation of T cells
  • linker for activation of T-cells family member 1
  • p36-38
  • pp36

Background

Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their developmentThis protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB110-60490
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
AF4066
Species: Hu
Applications: WB, CyTOF-ready, ICFlow
MAB7474
Species: Hu
Applications: WB, Simple Western, ICC
NBP1-47989
Species: Hu
Applications: WB, IHC, IHC-P
NBP2-36491
Species: Hu
Applications: WB, Flow, IHC, IHC-P, Flow-CS
NBP2-67360
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
NBP2-00764
Species: Hu
Applications: WB, Flow, IHC, IHC-P
NBP1-32945
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
NBP2-50465
Species: Hu
Applications: Flow, IHC, CyTOF-ready, Flow-CS
MAB7500
Species: Hu
Applications: WB, ICC
AF3846
Species: Hu, Mu, Rt
Applications: WB, IHC
MAB37861
Species: Hu
Applications: WB, Simple Western, ICC
NBP1-19371
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
AF467
Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, ICC
Supplier Logo

Publications for LAT Antibody (NBP2-27104) (0)

There are no publications for LAT Antibody (NBP2-27104).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for LAT Antibody (NBP2-27104) (0)

There are no reviews for LAT Antibody (NBP2-27104). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for LAT Antibody (NBP2-27104) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional LAT Products

Bioinformatics Tool for LAT Antibody (NBP2-27104)

Discover related pathways, diseases and genes to LAT Antibody (NBP2-27104). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for LAT Antibody (NBP2-27104)

Discover more about diseases related to LAT Antibody (NBP2-27104).
 

Pathways for LAT Antibody (NBP2-27104)

View related products by pathway.

PTMs for LAT Antibody (NBP2-27104)

Learn more about PTMs related to LAT Antibody (NBP2-27104).
 

Research Areas for LAT Antibody (NBP2-27104)

Find related products by research area.

Blogs on LAT.

CD3 (OKT3) as a marker of immune response efficiency
Our immune system is a powerful defense mechanism against infection, however different variables can cause our immune response to work for or against us.  CD3 (cluster of differentiation 3) is one component of our immune signal response that is co...  Read full blog post.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our LAT Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol LAT