LAT Products

Antibodies
Lysates
LAT Overexpression Lysate (Na ...
LAT Overexpression Lysate (Native)
NBP2-09156
Applications: WB
Proteins
LAT Recombinant Protein Antig ...
LAT Recombinant Protein Antigen
NBP1-81324PEP
Species: Hu
Applications: AC
LAT Recombinant Protein
LAT Recombinant Protein
NBP1-72479
Species: Hu
Applications: PAGE
RNAi
LAT RNAi
LAT RNAi
H00027040-R02
Species: Hu
Applications: RNAi, RNAi SP
LAT RNAi
LAT RNAi
H00027040-R03
Species: Hu
Applications: RNAi, RNAi SP
LAT RNAi
LAT RNAi
H00027040-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

LAT (linker for activation of T-cells) is involved in the T-cell antigen receptor (TCR) signal transduction pathway, and may play an important role downstream in activating protein tyrosine kinases (1). LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules (2). It has been found that Tyr191 and Tyr171 are required for T-cell activation and Tyr132 is required for the activation of PLCgamma1 and Ras signaling pathways, respectively. Tyr226 and Tyr191 are required for Vav binding, whereas Tyr171 and Tyr132 are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 27040
Alternate Names
  • p36-38
  • linker for activation of T-cells family member 1
  • 36 kDa phospho-tyrosine adapter protein
  • LAT1,36 kDa phospho-tyrosine adaptor protein
  • pp36
  • linker for activation of T cells

Research Areas for LAT

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Phospho-Specific
Signal Transduction

Bioinformatics Tool for LAT

Discover related pathways, diseases and genes to LAT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

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