Langerin/CD207 Antibody (LGRN/3136R) [PE]

• Reactivity: Hu
• Applications: ELISA
• Clone: LGRN/3136R
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: PE

Langerin/CD207 Antibody (LGRN/3136R) [PE] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant fragment (around aa74-213) of human Langerin/CD207 protein (exact sequence is proprietary) (Uniprot: Q9UJ71)
• Localization: Cell Surface & Cytoplasmic
• Marker: Marker of Langerhans Cells
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: CD207
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Langerin/CD207 Antibody (LGRN/3136R) [PE]

• CD207 antigen
• CD207 antigen, langerin
• CD207 molecule, langerin
• CD207
• CLEC4KLangerhans cell specific c-type lectin
• C-type lectin domain family 4 member K
• C-type lectin domain family 4, member K
• Langerin

Background

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Langerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CD207