Laminin alpha 3/Laminin-5 Antibody (546215) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 546215
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

Laminin alpha 3/Laminin-5 Antibody (546215) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human Laminin alpha 3/Laminin‑5 in direct ELISAs and Western blots. In direct ELISAs, no cross reactivity with recombinant human (rh) Laminin alpha 1, beta 1, gamma 2, or recombinant mouse Laminin alpha 4 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Laminin alpha 3/Laminin-5 Antibody (546215) [Alexa Fluor™ Plus 488]

• BM600 150kD subunit
• BM600
• E170
• Epiligrin 170 kDa subunit
• epiligrin alpha 3 subunit
• Epiligrin
• JEB2A
• JEB2B
• kalinin 165kD subunit
• Kalinin subunit alpha
• LAM3, alpha-3 subunit
• LAMA3
• laminin A3
• Laminin alpha 3
• laminin subunit alpha-3
• laminin-5 alpha 3 chain
• Laminin-5 subunit alpha
• Laminin5
• Laminin-5
• Laminin-6 subunit alpha
• Laminin-7 subunit alpha
• LAMNA
• LOCS
• nicein 150kD subunit
• Nicein subunit alpha

Background

Laminins are heterotrimeric, noncollagenous glycoproteins composed of alpha , beta , and gamma  chains. Through interactions with integrins, dystroglycan and other receptors, laminins contribute to cell differentiation, cell shape and migration, and maintenance of tissue phenotypes and survival. Laminin alpha 3/Laminin-5, also known as epiligrin, includes alpha 3, beta 3, and gamma 2 subunits. It is abundant in transitional epithelium, stratified squamous epithelia, lung mucosa and other epithelial glands and contributes to initiation and maintenance of epithelial cell anchorage to the underlying connective tissue. Within aa 21‑1713 of the alpha 3 subunit, human and mouse share 77% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.