Laminin alpha 3/Laminin-5 Products

Description

The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]

Bioinformatics

Product By Gene ID	3909
Alternate Names	BM600 150kD subunit BM600 E170 Epiligrin 170 kDa subunit epiligrin alpha 3 subunit JEB2A JEB2B kalinin 165kD subunit Kalinin subunit alpha LAM3, alpha-3 subunit laminin A3 laminin subunit alpha-3 laminin-5 alpha 3 chain Laminin-5 subunit alpha Laminin-6 subunit alpha Laminin-7 subunit alpha LAMNA LOCS nicein 150kD subunit Nicein subunit alpha