Kremen-2 Antibody [DyLight 650]

• Reactivity: Hu
• Applications: WB, Flow, CyTOF-ready
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 650

Kremen-2 Antibody [DyLight 650] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Kremen-2
  Gln19-Ala364
  Accession # Q8NCW0
• Specificity: Detects human Kremen-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross‑reactivity with recombinant mouse Kremen-2 and recombinant rat Kremen-2 is observed and less than 15% cross-reactivity with recombinant human Kremen-1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: KREMEN2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Kremen-2 Antibody [DyLight 650]

• Dickkopf receptor 2
• kremen protein 2
• Kremen2
• Kremen-2
• kringle containing transmembrane protein 2
• Kringle domain-containing transmembrane protein 2
• KRM2Kringle-containing protein marking the eye and the nose
• MGC10791
• MGC16709

Background

KREMEN2 encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KREMEN2