KLRC1/2/3 Antibody (20d5) [PE]

• Reactivity: Mu
• Applications: Flow
• Clone: 20d5
• Clonality: Monoclonal
• Host: Rat
• Conjugate: PE

KLRC1/2/3 Antibody (20d5) [PE] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: CHO cells transfected with B6 allele of NKG2A gene
• Specificity: Mouse NKG2 (Mr approx. 43 kDa)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Rat
• Gene: KLRC1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-28100. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for KLRC1/2/3 Antibody (20d5) [PE]

• CD159 antigen-like family member A
• CD159a antigen
• CD159a
• C-lectin type II protein
• killer cell lectin-like receptor subfamily C, member 1
• MGC13374
• natural killer cell lectin
• natural killer group protein 2
• NK cell receptor A
• NKG2
• NKG2-1/B activating NK receptor
• NKG2-A
• NKG2-A/B type II integral membrane protein
• NKG2-A/B-activating NK receptor
• NKG2-A/NKG2-B type II integral membrane protein
• NKG2AMGC59791
• NKG2-B

Background

The monoclonal antibody 20d5 reacts with an epitope common to the NKG2A, NKG2C and NKG2E isoforms of the CD94/NKG2 heterodimer, a member of the c-type lectin family of inhibitory receptors. Mouse CD94/NKG2 is a natural killer (NK) cell receptor for the non-classical MHC class I molecule Qa-1b. (2, 3) NKG2 is expressed on NK cells, lymphokine-activated killer (LAK) T cells, and some CD8+ memory T cells. Two-color immunofluorescent staining with the 20d5 antibody reveals two distinct NKG2+ phenotypes within the NK1.1+CD3- spleen cell population: NKG2hi (50%) and NKG2low (50%). With the exception of DBA/2J mice, NKG2 is expressed on NK1.1+ cells from all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). (1)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for KLRC1/2/3 Antibody (NBP1-28100PE)(1)

Publication using NBP1-28100PE

• Webb ER, Moreno-Vincente J, Easton A Et al. Cyclophosphamide depletes tumor infiltrating T regulatory cells and combined with anti-PD-1 therapy improves survival in murine neuroblastoma iScience 2022-09-13 [PMID: 36097618] (FLOW, Mouse)
  
  Details:
  Citation using the PE version of this antibody.

Bioinformatics

• Gene Symbol: KLRC1