Reactivity | HuSpecies Glossary |
Applications | WB, IHC, IP, B/N |
Clone | 325712 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human Kallikrein 4/Prostase/EMSP1 Ser27-Ser254 Accession # NP_004908 |
Specificity | Detects human Kallikrein 4/Prostase/EMSP1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Kallikrein 1, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, rhKallikrein B1, rhFactor VII, rhFactor X, rhFactor XI, rhHGFA, rhThrombin, and rhUPA-1 is observed. |
Source | N/A |
Isotype | IgG2b |
Clonality | Monoclonal |
Host | Mouse |
Gene | KLK4 |
Purity | Protein A or G purified from hybridoma culture supernatant |
Purity Statement | Protein A or G purified from hybridoma culture supernatant |
Endotoxin Note | <0.10 EU per 1 μg of the antibody by the LAL method. |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Purity | Protein A or G purified from hybridoma culture supernatant |
Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
Kallikrein 4 (KLK4), also known as prostase or EMSP1 (enamel matrix serine protease 1), is a serine protease of the human tissue kallikrein gene family (1). Among normal tissues, human KLK4 is specifically expressed in the prostate (2). It is over-expressed in prostate cancer and this expression is regulated by hormones including androgens, esterogen and progesterone (3). Recombinant human KLK4 readily activates pro-KLK3/PSA and pro-urokinase type plasminogen activator (uPA), indicating it may initiate events involving PSA and uPA in either normal or abnormal processes (4). KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins (5). In addition to being a secreted enzyme, it is also a nuclear protein (3, 6). The deduced amino acid sequence of human KLK4 consists of a signal peptide, a short pro region and a mature/active enzyme.
Secondary Antibodies |
Isotype Controls |
Diseases for Kallikrein 4/Prostase/EMSP1 Antibody (MAB35661)Discover more about diseases related to Kallikrein 4/Prostase/EMSP1 Antibody (MAB35661).
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PTMs for Kallikrein 4/Prostase/EMSP1 Antibody (MAB35661)Learn more about PTMs related to Kallikrein 4/Prostase/EMSP1 Antibody (MAB35661).
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