Kallikrein 4/Prostase/EMSP1 Antibody (325712) [Alexa Fluor™ Plus 647]

• Clone: 325712
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Kallikrein 4/Prostase/EMSP1 Antibody (325712) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Kallikrein 4/Prostase/EMSP1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Kallikrein 1, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, rhKallikrein B1, rhFactor VII, rhFactor X, rhFactor XI, rhHGFA, rhThrombin, and rhUPA-1 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 4/Prostase/EMSP1 Antibody (325712) [Alexa Fluor™ Plus 647]

• AI2A1
• ARM1
• EC 3.4.21
• EC 3.4.21.-
• EMSP
• EMSP1
• EMSP1MGC116827
• Enamel matrix serine proteinase 1
• kallikrein 4 (prostase, enamel matrix, prostate)
• Kallikrein 4
• kallikrein-4
• Kallikrein-like protein 1
• kallikrein-related peptidase 4
• KLK4
• KLK-L1MGC116828
• Prostase
• PRSS17enamel matrix serine protease 1
• PSTSandrogen-regulated message 1
• Serine protease 17

Background

Kallikrein 4 (KLK4), also known as prostase or EMSP1 (enamel matrix serine protease 1), is a serine protease of the human tissue kallikrein gene family (1). Among normal tissues, human KLK4 is specifically expressed in the prostate (2). It is over-expressed in prostate cancer and this expression is regulated by hormones including androgens, esterogen and progesterone (3). Recombinant human KLK4 readily activates pro-KLK3/PSA and pro-urokinase type plasminogen activator (uPA), indicating it may initiate events involving PSA and uPA in either normal or abnormal processes (4). KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins (5). In addition to being a secreted enzyme, it is also a nuclear protein (3, 6). The deduced amino acid sequence of human KLK4 consists of a signal peptide, a short pro region and a mature/active enzyme.

1. Yousef, G.M. and E.P. Diamandis (2001) Endocrine Rev. 22:184.
2. Nelson, P.S. et al. (1999) Proc. Natl. Acad. Sci. USA 96:3114.
3. Xi, Z. et al. (2004) Cancer Res. 64:2365.
4. Takayama, T.K. et al. (2001) Biochemistry 40:15341.
5. Simmer, J.P. and J.C. Hu (2002) Connect Tissue Res. 43:441.
6. Ryu, O.H. et al. (2002) Eur. J. Oral. Sci. 110:358.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.