Kallikrein 6/Neurosin Antibody

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Kallikrein 6/Neurosin was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 15 µg/mL Goat Anti-Human Kallikrein 6/Neurosin Antigen Affinity-purified ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Kallikrein 6/Neurosin Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kallikrein 6
Glu17-Lys244
Accession # Q92876
Specificity
Detects human Kallikrein 6 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Kallikrein 3, rhKallikrein 5, rhKallikrein 11, rhKallikrein 13, rhKallikrein 14, and rhKallikrein 15 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
KLK6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Immunoprecipitation 25 ug/mL
Reviewed Applications
Read 1 Review rated 4
using
AF2008 in the following applications:

Publications
Read Publications using
AF2008 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 6/Neurosin Antibody

  • Bssp
  • EC 3.4.21
  • EC 3.4.21.-
  • hK6
  • kallikrein 6 (neurosin, zyme)
  • Kallikrein 6
  • kallikrein-6
  • kallikrein-related peptidase 6
  • KLK6
  • Klk7
  • Neurosin
  • Protease M
  • protease, serine, 18
  • PRSS18
  • PRSS9
  • PRSS9MGC9355
  • Serine protease 18
  • Serine protease 9
  • SP59
  • Zyme

Background

Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (hKLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1-3). Known protein substrates of hKLK6 are myelin basic protein, the precursor of the A beta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of hKLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.

  1. Emami, N. and E.P. Diamandis (2007) Clin. Chim. Acta 381:78.
  2. Borgoño, C.A. and E.P. Diamandis (2004) Nat. Rev. Cancer 4:876.
  3. Paliouras, M. et al. (2007) Cancer Lett. 249:61.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Kallikrein 6/Neurosin Antibody (AF2008)(4)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IHC, IHC Not Specified, IHC Paraffin-embedded.


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(1)
IHC Not Specified
(1)
IHC Paraffin-embedded
(2)
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Human
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Review for Kallikrein 6/Neurosin Antibody (AF2008) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using AF2008:
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IHC-P
(1)
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Human
(1)
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Images Ratings Applications Species Date Details
 
reviewed by:
Anonymous
IHC-P Human 01/06/2015
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Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedSee PMID 20846516
SpeciesHuman

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Recent Reviews

4
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4
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1
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Anonymous
01/06/2015
Application: IHC-P
Species: Human

Bioinformatics

Gene Symbol KLK6
Uniprot