JAM-C Antibody

Product Discontinued

JAM-C Antibody Summary

• Immunogen: Peptide with sequence C-KQDGESYKNPGKPD corresponding to internal region (near C-Terminus) according to NP_116190.2.
• Epitope: internal region (near C-Terminus)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: JAM3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:2000
• Application Notes: WB: Preliminary experiments in human brain (cerebellum), lung and placenta lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for JAM-C Antibody

• CD323
• JAM-2
• JAM3
• JAMC
• JAM-C
• JAM-CFLJ14529
• junctional adhesion molecule 3JAM-3
• junctional adhesion molecule C

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for JAM-C Antibody (NBP1-47209)(1)

Publication using NBP1-47209

• Ueki T, Iwasawa K, Ishikawa H, Sawa Y. Expression of junctional adhesion molecules on the human lymphatic endothelium. Microvasc Res 2008-03-01 [PMID: 17822725]

Bioinformatics

• Gene Symbol: JAM3
• Entrez:
  • 83700(Human)
• Uniprot:
  • NP_116190.2(Human)