Western Blot: Jak1 [p Tyr1022] Antibody [NB100-82005] - Analysis of extracts from HT29 cells untreated or treated with UV using JAK1 [p Tyr1022] antibody.
Immunohistochemistry-Paraffin: Jak1 [p Tyr1022] Antibody [NB100-82005] - Analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 (phospho-Tyr1022) antibody
Western Blot: Jak1 [p Tyr1022] Antibody [NB100-82005] - Analysis of extract from thyroid cancer cell line BHP cells (BHP 5, 14, 15 and 17), using JAK1 (phospho-Tyr1022) antibody. Only BHP 5, 15 and 17 can detect the ...read more
130 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for Jak1 [p Tyr1022] Antibody
JAK1Atyrosine-protein kinase JAK1
Janus kinase 1EC 126.96.36.199
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterised by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signalling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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