Jak1 Products

Antibodies
Jak1 Antibody (413104) [Uncon ...
Jak1 Antibody (413104) [Unconjugated]
MAB4260
Species: Hu, Mu, Rt
Applications: WB, IHC, CyTOF-ready, ICC, ICFlow
Host: Rat Monoclonal
Jak1 Antibody [Unconjugated]
Jak1 Antibody [Unconjugated]
AF602
Species: Mu, Rt
Applications: WB, ICC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Jak1 [p Tyr1022] Antibody
Jak1 [p Tyr1022] Antibody
NB100-82005
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Jak1 Overexpression Lysate (N ...
Jak1 Overexpression Lysate (Native)
NBL1-12093
Applications: WB
Proteins
Recombinant Human Jak1 Protei ...
Recombinant Human Jak1 Protein
H00003716-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Jak1 RNAi
Jak1 RNAi
H00003716-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterised by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signalling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 3716
Alternate Names
  • EC 2.7.10
  • JAK1B
  • JAK-1
  • JTK3
  • JAK1Atyrosine-protein kinase JAK1
  • Janus kinase 1EC 2.7.10.2

Research Areas for Jak1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction

Bioinformatics Tool for Jak1

Discover related pathways, diseases and genes to Jak1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Jak1 Blog Posts

Check out the latest blog posts on Jak1.
Using a STAT3 antibody in chromatin immunoprecipitation (ChIP)
Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.
Read more Jak1 related blogs.