Jak1 Products

Antibodies
Jak1 Antibody (452804) [Uncon ...
Jak1 Antibody (452804) [Unconjugated]
MAB42601
Species: Hu, Mu
Applications: WB, Simple Western
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Jak1 Antibody [Unconjugated]
Jak1 Antibody [Unconjugated]
AF602
Species: Mu, Rt
Applications: WB, ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
ELISA Kits
Human Jak1 ELISA Kit (Colorim ...
Human Jak1 ELISA Kit (Colorimetric)
NBP2-80249
Species: Hu
Applications: ELISA
Lysates
Jak1 Overexpression Lysate
Jak1 Overexpression Lysate
NBL1-12093
Species: Hu
Applications: WB
Proteins
Recombinant Human Jak1 GST (N ...
Recombinant Human Jak1 GST (N-Term...
H00003716-Q01
Species: Hu
Applications: WB, ELISA, MA, AP

Description

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterised by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signalling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Bioinformatics

Entrez Mouse
Human
Rat
Uniprot Human
Human
Human
Human
Alternate Names
  • EC 2.7.10
  • JAK-1
  • JAK1Atyrosine-protein kinase JAK1
  • JAK1B
  • Janus kinase 1EC 2.7.10.2
  • JTK3

Research Areas for Jak1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction