Islet-1 Antibody (OTI2D8) [Janelia Fluor® 669]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: OTI2D8
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

Islet-1 Antibody (OTI2D8) [Janelia Fluor® 669] Summary

• Immunogen: Human recombinant protein fragment corresponding to amino acids 134-349 of human ISL1(NP_002193) produced in E.coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ISL1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Islet-1 Antibody (OTI2D8) [Janelia Fluor® 669]

• insulin gene enhancer protein ISL-1
• ISL LIM homeobox 1
• ISL1 transcription factor, LIM/homeodomain
• ISL1 transcription factor, LIM/homeodomain, (islet-1)
• ISL1
• Isl-1
• Islet1
• Islet-1

Background

Islet 1 encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ISL1