Western blot shows lysates of human liver and kidney tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human IRF8 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5117) followed by HRP-conjugated ...read more
IRF8 was detected in immersion fixed paraffin-embedded sections of human lymphoma using 5 µg/mL Sheep Anti-Human IRF8 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5117) overnight at4 °C. Tissue was ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Immunogen affinity purified
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for IRF8 Antibody
interferon consensus sequence binding protein 1
Interferon consensus sequence-binding protein
interferon regulatory factor 8
IRF8 (interferon regulatory factor 8; also ICSBP) is a 50 kDa member of the IRF family of proteins. It is expressed in myeloid, dendritic and B cells and interacts with PU.1 to regulate the expression of TLR4, IL-18, IL-12p35, and PTPN13, a Fas-associated phosphatase that blocks Fas-induced apoptosis. Human IRF8 is 426 amino acids (aa) in length. It contains an N-terminal DNA-binding basic region (aa 9-110) and at least one regulatory phosphorylation site at Tyr95. Over aa 255-426, human IRF8 shares 90% and 88% aa sequence identity with canine and mouse IRF8, respectively.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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