IRF8 Products

Antibodies
IRF8 Antibody
IRF8 Antibody
AF5117
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
IRF8 Antibody (809926)
IRF8 Antibody (809926)
MAB5117
Species: Hu
Applications: WB, Simple Western, IHC
Host: Mouse Monoclonal
IRF8 Antibody
IRF8 Antibody
NBP1-83123
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
IRF8 Overexpression Lysate (N ...
IRF8 Overexpression Lysate (Native)
NBP2-08141
Applications: WB
Proteins
IRF8 Recombinant Protein
IRF8 Recombinant Protein
H00003394-P01
Species: Hu
Applications: WB, ELISA, PA
IRF8 Partial Recombinant Prot ...
IRF8 Partial Recombinant Protein
H00003394-Q01
Species: Hu
Applications: WB, ELISA, PA
IRF8 Recombinant Protein Anti ...
IRF8 Recombinant Protein Antigen
NBP1-83123PEP
Species: Hu
Applications: AC
RNAi
IRF8 RNAi
IRF8 RNAi
H00003394-R01
Species: Hu

Description

Interferon regulatory factor 8 (IRF8) / Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA binding domain in the N terminal region and a divergent C terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN alpha and IFN beta. IRF family proteins also control expression of IFN alpha and IFN beta regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN inducible MHC class I genes (the interferon consensus sequence (ICS)). Unlike IRF3, IRF8 appears to act as a negative regulator of IFN induced genes in most cases, but IRF8 mediates activation of NF kappaB by the toll like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 3394
Alternate Names
  • interferon consensus sequence binding protein 1
  • IRF-8ICSBP1
  • ICSBPH-ICSBP
  • Interferon consensus sequence-binding protein
  • interferon regulatory factor 8

Bioinformatics Tool for IRF8

Discover related pathways, diseases and genes to IRF8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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