IRF6 Antibody (503404) [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 503404
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

IRF6 Antibody (503404) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human IRF6
  Ala176-Gln366
  Accession # O14896
• Specificity: Detects human and mouse IRF6 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IRF6 Antibody (503404) [Alexa Fluor® 350]

• interferon regulatory factor 6
• IRF6
• IRF-6
• LPS
• OFC6
• OFC6PPS
• PIT
• PPS
• Van der Woude syndrome
• VWS
• VWS1

Background

Interferon regulatory factor 6 (IRF6), is a transcription factor that controls the proliferation and differentiation of epidermal and epithelial cells. IRF6 interacts with maspin in normal mammary epithelial cells but is down‑regulated during tumor progression. IRF6 polymorphisms cause Van der Woude and popliteal pterygium syndromes of skin, limb, and craniofacial development that are characterized by cleft lip, cleft palate, or lip pits. IRF6 contains an N-terminal DNA binding domain that is homologous to that in other IRF proteins. Within aa 176‑366 of the C‑terminal domain, human IRF6 shares 98% aa sequence identity with mouse and rat IRF6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.