Integrin beta 3/CD61 Antibody (BV4)

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA, Func, IHC, IP
• Clone: BV4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.1 mg/ml

Integrin beta 3/CD61 Antibody (BV4) Summary

• Immunogen: Mouse Integrin alpha V beta 3
• Specificity: The monoclonal antibody BV4 recognizes human beta3 integrin subunit present in Platelet glycoprotein GPIIb-IIIa (integrin alphaIIb/beta3, CD41/CD61) and in the vitronectin receptor (integrin alphaV/beta3, CD51/CD61).
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGB3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Functional
  • Immunoassay
  • Immunohistochemistry 1:50
  • Immunohistochemistry-Frozen 1:50
  • Immunohistochemistry-Paraffin 1:50
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:50

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 23857293). Mouse reactivity reported in scientific literature (PMID: 28050799).

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS containing 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein G purified

Alternate Names for Integrin beta 3/CD61 Antibody (BV4)

• CD61 antigen
• CD61
• GP3A
• GP3Aplatelet glycoprotein IIIa
• GPIIIA
• GPIIIaintegrin beta-3
• INGRB3
• Integrin beta 3
• integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
• ITG B3
• ITGB3
• Platelet membrane glycoprotein IIIa

Background

Human Integrin beta 3 (CD61) antigen is expressed on platelets, megakaryocytes, macrophages, osteoclasts and synovial lining cells. The integrin beta 3 chain of the vitronectin receptor and GPIIb/IIIa complex. The beta 3 integrin chain is a 90-110 kDa glycoprotein polypeptide which is expressed on platelets, megakaryocytes, macrophages, osteoclasts and synovial lining cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin beta 3/CD61 Antibody (NB600-1342)(10)

Publications using NB600-1342

• Rehman R, Miller M, Krishnamurthy SS et al. Met/HGFR triggers detrimental reactive microglia in TBI Cell reports 2022-12-27 [PMID: 36577378] (ICC/IF, Mouse)
• Zhang J, Wang L, Li C et al. Letrozole promotes the expression of integrin alpha v beta 3 and HOXA10 in endometrium of endometriosis Systems biology in reproductive medicine 2021-12-28 [PMID: 34962452] (WB)
• Xing Q, Feng Y, Sun H Et al. Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells Experimental cell research 2021-10-06 [PMID: 34626585]
• Park MH, Kim AK, Manandhar S et al. CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity Elife 2019-08-20 [PMID: 31429823] (WB)
• Flamini MI, Uzair ID, Pennacchio GE et al. Thyroid Hormone Controls Breast Cancer Cell Movement via Integrin aV/b3/SRC/FAK/PI3-Kinases. Horm Cancer [PMID: 28050799] (WB, Mouse)
• Kim JH, Kim YH, Kim YJ et al. Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using 68Ga-NOTA-c(RGDyK). Angiogenesis 2013-07-16 [PMID: 23857293] (IHC-P, Rat)
• Tang NH, Chen YL, Wang XQ et al. N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells. BMC Cancer. 2010-10-01 [PMID: 20939933]
• Neto DS, Pantaleao L, de Sa BC et al. Alpha-v-beta3 integrin expression in melanocytic nevi and cutaneous melanoma. J Cutan Pathol. 2007-11-01 [PMID: 17944725]
• Kimmins S, Lim HC, MacLaren LA et al. Immunohistochemical localization of integrin alpha V beta 3 and osteopontin suggests that they do not interact during embryo implantation in ruminants. Reprod Biol Endocrinol. 2004-04-01 [PMID: 15115551]
• Soldi R, Mitola S, Strasly M et al. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 1999-02-01 [PMID: 10022831]

FAQs for Integrin beta 3/CD61 Antibody (NB600-1342). (Showing 1 - 1 of 1 FAQs).

1. Our customer said he has searched for a long time for the Integrin alpha V beta 3 Antibody which has been tested for IHC-P. So he is happy to see NB600-1342, but worried at the same time if the info. From the product page is reliable since there is no image to prove. Would you please help confirm if NB600-1342 is suitable for IHC with paraffin-embedded sections?
   • NB600-1342 has been validated for use in IHC-P. We do not have an image as this has been tested by an innovator who did not wish for their image to be published. I hope this reassures your customer. If this antibody does not work in IHC-P we will provide a full refund for the antibody.

Bioinformatics

• Gene Symbol: ITGB3
• Entrez:
  • 3690(Human)
• Uniprot:
  • P05106()