Integrin beta 3/CD61 Antibody (256809) [Allophycocyanin]

Human peripheral blood monocytes were stained with Mouse Anti-Human Integrin beta 3/CD61 APC-conjugated Monoclonal Antibody (Catalog # FAB2266A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 256809
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

Integrin beta 3/CD61 Antibody (256809) [Allophycocyanin] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Integrin beta 3/CD61
  Gly27-Asp718
  Accession # P05106
• Specificity: Detects human Integrin beta 3/CD61 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human Integrin beta 1, beta 2, recombinant mouse Integrin beta 4, or beta 6 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGB3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin beta 3/CD61 Antibody (256809) [Allophycocyanin]

• CD61 antigen
• CD61
• GP3A
• GP3Aplatelet glycoprotein IIIa
• GPIIIA
• GPIIIaintegrin beta-3
• INGRB3
• Integrin beta 3
• integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
• ITG B3
• ITGB3
• Platelet membrane glycoprotein IIIa

Background

Integrin beta 3, also called CD61, associates with the Integrin alpha IIb or alpha V subunits to form heterodimeric receptors for collagens, fibronectin, vitronectin, fibrinogen, Von willebrand factor or thrombospondin. alpha IIb/ beta 3, also known as GPIIb IIIa (Glycoprotein IIb-IIIa), is expressed on platelets. alpha V/ beta 3, also known as vitronectin receptor, is expressed on endothelial cells, some B cells, platelets and monocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin beta 3/CD61 Antibody (FAB2266A)(1)

Publication using FAB2266A

• Park-Min K, Lee E, Moskowitz N, Lim E, Lee S, Lorenzo J, Huang C, Melnick A, Purdue P, Goldring S, Ivashkiv L Negative regulation of osteoclast precursor differentiation by CD11b and beta2 integrin-B-cell lymphoma 6 signaling. J Bone Miner Res, 2013-01-01;28(1):135-49. 2013-01-01 [PMID: 22893614] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: ITGB3
• Uniprot:
  • P05106()