Integrin alpha 5/CD49e Antibody (238307) [Phycoerythrin]

K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human Integrin a5/CD49e PE-conjugated Monoclonal Antibody (Catalog # FAB1864P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 238307
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

Integrin alpha 5/CD49e Antibody (238307) [Phycoerythrin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Integrin alpha 5/CD49e
  Phe42-Tyr995
  Accession # P08648
• Specificity: Detects human Integrin alpha 5/CD49e.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA5
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha 5/CD49e Antibody (238307) [Phycoerythrin]

• CD49 antigen-like family member E
• CD49e antigen
• CD49e
• Fibronectin receptor subunit alpha
• fibronectin receptor, alpha subunit
• FNRAVLA5A
• Integrin alpha 5
• integrin alpha-5
• Integrin alpha-F
• integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
• ITGA5
• very late activation protein 5, alpha subunit
• VLA-5 alpha
• VLA-5

Background

The Integrin alpha 5 subunit, also called CD49e, associates with the Integrin beta 1 subunit (CD29) to form the VLA-5 complex. It functions as a receptor for fibronectin and is expressed on fibroblasts, endothelial cells, epithelial cells, platelets and some melanoma cell lines (1, 2).

1. Springer, T.A. et al. (1982) Immunol. Rev. 68:171.
2. Te Velde, A. et al. (1988) J. Immunol. 140:1548.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 5/CD49e Antibody (FAB1864P)(2)

Publications using FAB1864P

• Y Basmaeil, E Bahattab, A Al Subayyi, HB Kulayb, M Alrodayyan, M Abumaree, T Khatlani Decidua Parietalis Mesenchymal Stem/Stromal Cells and Their Secretome Diminish the Oncogenic Properties of MDA231 Cells In Vitro Cells, 2021-12-10;10(12):. 2021-12-10 [PMID: 34944000] (Flow Cytometry, Human)
• Hosomi S, Oshitani N, Kamata N, Sogawa M, Okazaki H, Tanigawa T, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis. Clin. Exp. Immunol., 2010-11-19;163(2):215-24. 2010-11-19 [PMID: 21087446] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: ITGA5
• Uniprot:
  • P08648()