Integrin alpha 2b/CD41 Antibody (MWReg30)

Images

 
Flow Cytometry: Integrin alpha 2b/CD41 Antibody (MWReg30) [NBP1-43415] - Analysis using the Biotin conjugate of NBP1-43415. Staining of mouse platelets with Anti-Mouse/Rat CD61 (Integrin beta 3) FITC and 0.06 ug of Rat ...read more
Flow Cytometry: Integrin alpha 2b/CD41 Antibody (MWReg30) [NBP1-43415] - Staining of mouse platelets with 0.125 ug of Rat IgG1 Isotype Control Purified (left) or 0.125 ug of Anti-Mouse CD41 Purified (right) followed by ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA, Flow, IP
Clone
MWReg30
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Integrin alpha 2b/CD41 Antibody (MWReg30) Summary

Immunogen
The immunogen for this antibody was CD41.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Rat
Gene
ITGA2B
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunoprecipitation 1:10-1:500
Application Notes
This MWReg30 antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.25 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
Publications
Read Publication using
NBP1-43415 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Integrin alpha 2b/CD41 Antibody (MWReg30)

  • CD41 antigen
  • CD41
  • CD41BHPA3
  • GP2B
  • GP2Bintegrin alpha-IIb
  • GPalpha IIb
  • GPIIb
  • GTA
  • HPA3
  • Integrin alpha 2b
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
  • ITGA2b
  • ITGAB
  • platelet fibrinogen receptor, alpha subunit
  • Platelet membrane glycoprotein IIb
  • platelet-specific antigen BAK

Background

The MWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alphaIIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin betaIII) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin. Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha 2b/CD41 Antibody (NBP1-43415)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-P.


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IHC-P
(1)
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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-43415AF405
Alexa Fluor 488 Labeled NBP1-43415AF488
Alexa Fluor 647 Labeled NBP1-43415AF647
Alexa Fluor 700 Labeled NBP1-43415AF700
Allophycocyanin Labeled NBP1-43415APC
Biotin Labeled NBP1-43649
DyLight 350 Labeled NBP1-43415UV
DyLight 405 Labeled NBP1-43415V
DyLight 488 Labeled NBP1-43415G
DyLight 680 Labeled NBP1-43415FR
DyLight 755 Labeled NBP1-43415IR
FITC Labeled NBP1-44012
PE Labeled NBP1-43415PE
PerCP Labeled NBP1-43415PCP

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Bioinformatics

Gene Symbol ITGA2B
Entrez