INSRR/IR-related receptor Antibody (326903) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB
• Clone: 326903
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

INSRR/IR-related receptor Antibody (326903) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human INSRR
  Leu24-Leu923
  Accession # P14616
• Specificity: Detects human INSRR in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human Insulin receptor is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for INSRR/IR-related receptor Antibody (326903) [Alexa Fluor® 405]

• EC 2.7.10
• EC 2.7.10.1
• INSRR
• insulin receptor-related protein
• insulin receptor-related receptor
• IRR
• IRRIR-related receptor

Background

INSRR is a 175 kDa orphan receptor belonging to the insulin receptor subfamily of the receptor tyrosine kinase family.It is expressed in neuroblastoma and many adult tissues, including kidney, heart, pancreas, liver and skeletal muscle. INSRR is synthesized as a single chain type I transmembrane glycoprotein precursor and undergoes proteolytic processing to generate the mature disulfide linked alpha 2/ beta 2 tetrameric receptor. The alpha subunit is localized extracellularly while the transmembrane beta subunit contains an extracellular domain, a transmembrane segment and a cytoplasmic kinase domain. The extracellular domain of human INSRR shares approximately 90% amino acid sequence identity with the mouse protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.