Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn't bind any of IR and IGF-1R known ligands (1-2). In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown (3).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
|
| Product By Gene ID |
3645 |
| Alternate Names |
- EC 2.7.10
- EC 2.7.10.1
- INSRR
- insulin receptor-related protein
- insulin receptor-related receptor
- IRR
- IRRIR-related receptor
|
Research Areas for INSRR/IR-related receptor
Find related products by research area and learn more about each of the different research areas below.
Protein Kinase
