IMP2/IGF2BP2 Antibody

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Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, A431 human epithelial carcinoma cell line, Caco-2 human colorectal adenocarcinoma cell line, NIH-3T3 mouse embryonic fibroblast cell line, ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

IMP2/IGF2BP2 Antibody Summary

Immunogen
E. coli-derived recombinant human IMP2
Met1-Thr220
Accession # Q9Y6M1
Specificity
Detects endogenous human, mouse and rat IMP2 isoforms in Western blots. Reactivity with other IMP family members is unknown.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IGF2BP2
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IMP2/IGF2BP2 Antibody

  • Hepatocellular carcinoma autoantigen p62
  • IF2B2
  • IGF2BP2
  • IGF-II mRNA-binding protein 2
  • IMP2
  • IMP-2IGF2 mRNA-binding protein 2
  • IMP2VICKZ family member 2
  • insulin-like growth factor 2 mRNA binding protein 2
  • insulin-like growth factor 2 mRNA-binding protein 2
  • p62
  • VICKZ2

Background

IMP2 (IGF-II mRNA-binding protein 2; also VICKZ family member 2) is a 62 kDa member of the RRM IMP/VICKZ family of proteins. It is expressed in oocytes, spermatogonia, Leydig cells and follicular granulosa cells. IMP2 binds to AUF1, a binding protein for the AU-rich motifs of mRNA, and facilitates the degradation of cytokine and protooncogene mRNAs. Human IMP2 is 556 amino acids (aa) in length. It contains two RNA recognition regions (aa 3‑76 and 82‑157), and four KH domains (aa 193‑532) that mediate RNA binding. There are multiple splice variants. One shows an insertion of 43 aa after Asn357, a second shows a 17 aa substitution for the N-terminal 80 aa, a third shows a combination of the prior two, and a fourth shows a 15 aa substitution for aa 414‑556. Over aa 1‑220, human IMP2 is 89% aa identical to mouse IMP2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IGF2BP2
Uniprot