IMP2/IGF2BP2 Antibody Summary
Immunogen |
E. coli-derived recombinant human IMP2 Met1-Thr220 Accession # Q9Y6M1 |
Specificity |
Detects endogenous human, mouse and rat IMP2 isoforms in Western blots. Reactivity with other IMP family members is unknown. |
Source |
N/A |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Goat |
Gene |
IGF2BP2 |
Purity Statement |
Antigen Affinity-purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution. |
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative |
No Preservative |
Concentration |
LYOPH |
Reconstitution Instructions |
Reconstitute at 0.2 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for IMP2/IGF2BP2 Antibody
Background
IMP2 (IGF-II mRNA-binding protein 2; also VICKZ family member 2) is a 62 kDa member of the RRM IMP/VICKZ family of proteins. It is expressed in oocytes, spermatogonia, Leydig cells and follicular granulosa cells. IMP2 binds to AUF1, a binding protein for the AU-rich motifs of mRNA, and facilitates the degradation of cytokine and protooncogene mRNAs. Human IMP2 is 556 amino acids (aa) in length. It contains two RNA recognition regions (aa 3-76 and 82-157), and four KH domains (aa 193-532) that mediate RNA binding. There are multiple splice variants. One shows an insertion of 43 aa after Asn357, a second shows a 17 aa substitution for the N-terminal 80 aa, a third shows a combination of the prior two, and a fourth shows a 15 aa substitution for aa 414-556. Over aa 1-220, human IMP2 is 89% aa identical to mouse IMP2.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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