ZnT-8/SLC30A8 Antibody (815039) [Unconjugated]

Images

 
ZnT‑8 was detected in immersion fixed paraffin-embedded sections of human pancreas using Mouse Anti-Human ZnT‑8 Monoclonal Antibody (Catalog # MAB7936) at 15 µg/mL overnight at 4 °C. Before incubation with the ...read more
PANC-1 human cell line was stained with Mouse Anti-Human ZNT-8 Monoclonal Antibody (Catalog # MAB7936, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by APC-conjugated ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, CyTOF-ready, Flow
Clone
815039
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

ZnT-8/SLC30A8 Antibody (815039) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human ZnT‑8
Lys268-Pro359
Accession # Q8IWU4
Specificity
Detects human ZnT‑8 in ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
SLC30A8
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunohistochemistry 8-25 ug/mL
  • Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ZnT-8/SLC30A8 Antibody (815039) [Unconjugated]

  • SLC30A8
  • solute carrier family 30 (zinc transporter), member 8
  • Solute carrier family 30 member 8
  • zinc transporter 8
  • zinc transporter ZnT-8
  • ZnT8
  • ZnT-8
  • ZNT8ZnT-8

Background

ZnT-8 (Zinc Transporter 8; also SLC30A8) is a 35-40 kDa member of the SLC (solute carrier)-30A subfamily, CDF family of proteins. It is expressed by pancreatic beta ‑cells and alpha -cells, B cells, and adipocytes and is known to play a role in Zn transport. In particular, ZnT-8 appears to transport zinc from the cytosol into secretory vesicles which, in the case of beta -cells, provides a necessary component for proper insulin processing and granule storage. Furthermore, it appears to facilitate glucose‑mediated insulin release. Human ZnT-8 is a multipass transmembrane (TM) protein that is 369 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-79) followed by six TM segments (aa 80-266) and a 103 aa C-terminal cytoplasmic tail. There is a key His-rich motif in the second cytoplasmic loop (aa 197‑205). ZnT-8 forms homodimers and possibly oligomers. There is one alternative start site at Met50. Over aa 268-359, human ZnT-8 shares 79% aa sequence identity with mouse ZnT-8.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Diseases for ZnT-8/SLC30A8 Antibody (MAB7936)

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Pathways for ZnT-8/SLC30A8 Antibody (MAB7936)

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Bioinformatics

Gene Symbol SLC30A8
Uniprot