IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Alexa Fluor® 532]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 911425
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Alexa Fluor® 532] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2
  Met1-Phe514
  Accession # P12268
• Specificity: Detects human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 in direct ELISAs. Detects human, mouse and rat IMPDH2 in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Alexa Fluor® 532]

• EC 1.1.1.205
• IMDH2
• IMP (inosine 5'-monophosphate) dehydrogenase 2
• IMP (inosine monophosphate) dehydrogenase 2
• IMP Dehydrogenase 2
• IMP Oxireductase 2
• IMPD 2
• IMPD2
• IMPD2IMP oxireductase 2
• IMPDH 2
• IMPDH2
• IMPDH-II
• inosine 5' phosphate dehydrogenase 2
• inosine monophosphate dehydrogenase type II
• inosine-5'-monophosphate dehydrogenase 2

Background

IMP Dehydrogenase 2 (IMPDH2), also known as type II Inosine 5'-Monophosphate Dehydrogenase and IMPD2, is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis. Along with closely related enzyme IMPDH1, IMPDH2 catalyzes the conversion of Inosine 5’-Phosphate (IMP) to Xanthosine 5’-Phosphate (XMP), and is responsible for maintaining the cellular guanine deoxy- and ribonucleotide pools required for DNA and RNA synthesis, respectively. IMPDH2 regulation is associated with cellular proliferation, transformation and differentiation, and its levels are selectively upregulated in neoplastic and replicating cells. Therefore, it has been evaluated as a target for anti-tumor, anti-infective and immunosuppressive drugs.  Human IMPDH2 is a 56 kDa protein that shares 84% amino acid (aa) identity with human IMPDH1, and 98% aa identity with mouse and rat IMPDH2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.