IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [mFluor Violet 610 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 911425
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 610 SE

IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [mFluor Violet 610 SE] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2
  Met1-Phe514
  Accession # P12268
• Specificity: Detects human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 in direct ELISAs. Detects human, mouse and rat IMPDH2 in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: IMPDH2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [mFluor Violet 610 SE]

• EC 1.1.1.205
• IMDH2
• IMP (inosine 5'-monophosphate) dehydrogenase 2
• IMP (inosine monophosphate) dehydrogenase 2
• IMP Dehydrogenase 2
• IMP Oxireductase 2
• IMPD 2
• IMPD2
• IMPD2IMP oxireductase 2
• IMPDH 2
• IMPDH2
• IMPDH-II
• inosine 5' phosphate dehydrogenase 2
• inosine monophosphate dehydrogenase type II
• inosine-5'-monophosphate dehydrogenase 2

Background

IMPDH2 encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IMPDH2