ILT2/CD85j/LILRB1 Antibody (292305) [Alexa Fluor® 405] Summary
Mouse myeloma cell line NS0-derived recombinant human LILRB1/CD85j/ILT2
Accession # Q8NHL6
Detects human LILRB1/CD85j/ILT2 in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) ILT4, rhILT5, rhLIR6 or rhLIR8 is observed.
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- Flow Cytometry 0.25-1 ug/10^6 cells
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for ILT2/CD85j/LILRB1 Antibody (292305) [Alexa Fluor® 405]
- CD85 antigen-like family member J
- CD85j antigen
- Ig-like transcript 2
- Immunoglobulin-like transcript 2
- leukocyte Ig-like receptor-1
- Leukocyte immunoglobulin-like receptor 1
- leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform
- leukocyte immunoglobulin-like receptor subfamily B member 1
- leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains)
- LIR1LIR-1MIR-7CD85MIR7CD85 antigen
- member 1
- Monocyte/macrophage immunoglobulin-like receptor 7
The immunoglobulin-like transcript (ILT) family of activating and inhibitory type immunoreceptors are expressed on many leukocyte subsets and function in the regulation of immune responses (1‑3). This family was also named leukocyte Ig-like receptors (LIR) and monocyte/macrophage Ig-like receptors (MIR). ILTs share significant homology with killer cell Ig-like receptors (KIR). The ILT genes are located on human chromosome 19q13.4 in the leukocyte receptor complex, which also include the genes encoding KIRs (4). With the exception of ILT-6, which is a soluble molecule, all ILT family members are type I transmembrane proteins having two or four extracellular Ig-like domains (2, 3). One subset of the ILT receptors (referred to as subfamily B of the LIRs) has long cytoplasmic tails containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that inhibit signaling events by recruiting SH2-containing protein tyrosine phosphatase-1. Another subset of the ILT receptors (referred to as subfamily A of the LIRs) contains activating receptors with short cytoplasmic regions that lack signal transduction motifs. These receptors contain a basic arginine residue within their transmembrane domains, which allows association with Fc R gamma, an immunoreceptor tyrosine-based activation motif (ITAM)-bearing signal adapter protein (1‑3). ILT2, also known as LIR1, MIR7, and CD85j, is expressed on most monocytes, dendritic cells, and mature B cells (1‑3). It is also expressed on small percentages of T cells and NK cells. ILT2 has four extracellular Ig-like domains and three cytoplasmic ITIMs. It functions as an inhibitory receptor that prevents cellular activation. ILT2 has been shown to bind classical (HLA-A and -B) and nonclassical (HLA-G1, -E and -F) MHC class I molecules (MHCI) (1‑3). ILT2 also binds with high affinity to an MHC class I homologue from human cytomegalovirus (3). Ligation of ILT2 by MHC class I may function to poise cellular activation thresholds and inhibit various leukocyte effector mechanisms that are regulated by MHC class I molecules on target cells.
- Allen, D. et al. (2000) Immunobiol. 202:34.
- Colonna, M. et al. (1999) J. Leukocyte Biol. 66:375.
- Borges, L. and D. Cosman (2000) Cytokine Growth Factor Rev. 11:209.
- Young, N. et al. (2001) Immunogenetics 53:270.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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