ILT2/CD85j/LILRB1 Products

Description

LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family (1). Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs (2). Alternative splicing generates an additional isoform that lacks the transmembrane and cytoplasmic regions (3). LILRB1 is expressed on the surface of B cells and monocytes, as well as subsets of NK cells, memory/effector CD8+ T cells, gamma δ T cells, and monocyte-derived dendritic cells (3-7). LILRB1 binds to MHC-I as well as non-classical MHC-I molecules (e.g. HLA-F, HLA-G, and HLA-B27) and the MHC-I mimetic UL18 encoded by cytomegalovirus (3, 5, 8-10). R&D Systems in-house testing indicates that LILRB1 also binds to Angiopoietin-like 7. Ligation of LILRB1 inhibits the antigen induced proliferation and activation of CD8+ T cells, CD4+ T cells, NK cells, and gamma δ T cells (3, 4, 11-13). On dendritic cells, ligation inhibits the production of IL-10, IL-12p70, and TGF-beta and protects from Fas-mediated apoptosis (7). Our Avi-tag Biotinylated human LILRB1 His-tag protein features biotinylation at a single site contained within the Avi-tag, a unique 15 amino acid peptide. Protein orientation will be uniform when bound to streptavidin-coated surface due to the precise control of biotinylation and the rest of the protein is unchanged so there is no interference in the protein's bioactivity.

Bioinformatics

Uniprot	Q8NHL6.1
Product By Gene ID	10859
Alternate Names	CD85 antigen-like family member J CD85j antigen CD85j Ig-like transcript 2 ILT2 ILT-2 ILT2FLJ37515 Immunoglobulin-like transcript 2 leukocyte Ig-like receptor-1 Leukocyte immunoglobulin-like receptor 1 leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform leukocyte immunoglobulin-like receptor subfamily B member 1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains) LILRB1 LIR1 LIR1LIR-1MIR-7CD85MIR7CD85 antigen member 1 MIR7 Monocyte/macrophage immunoglobulin-like receptor 7