IL6R Antibody (rhPM-1 (Tocilizumab)) - Azide and BSA Free

• Reactivity: Hu
• Applications: ELISA, ICC/IF, Inhibition Activity
• Clone: rhPM-1 (Tocilizumab)
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

IL6R Antibody (rhPM-1 (Tocilizumab)) - Azide and BSA Free Summary

• Immunogen: The original antibody was generated by CDR grafting of mouse PM-1 antibody onto human REI and NEW framework regions to create rhPM-1.
• Specificity: Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Human
• Gene: IL6R
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/ Immunofluorescence
  • Inhibition Activity
• Application Notes: NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Packaging, Storage & Formulations

• Storage: Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
• Buffer: PBS
• Preservative: 0.02% Proclin 300
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for IL6R Antibody (rhPM-1 (Tocilizumab)) - Azide and BSA Free

• biosimilar antibody
• biosimilars
• CD126 antigen
• CD126
• gp80
• IL-6 receptor subunit alpha
• IL-6R 1
• IL-6R subunit alpha
• IL-6R-1
• IL6RA
• IL-6RA
• IL-6R-alpha
• interleukin 6 receptor alpha subunit
• interleukin 6 receptor
• interleukin-6 receptor subunit alpha
• Membrane glycoprotein 80
• MGC104991

Background

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL6R Antibody (NBP2-75192)(2)

Publications using NBP2-75192

• Nunes-Santos CJ, Kuehn H, Boast B et al. Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling Nature communications 2023-06-22 [PMID: 37349293] (FLOW, Human)
• J Dahmen, A Vermeulen, S Payne, C Lippmeier Thraustochytrid hosts for expression of proteins relevant to SARS-CoV-2 intervention PLoS ONE, 2023-04-12;18(4):e0283592. 2023-04-12 [PMID: 37043472]

Bioinformatics

• Gene Symbol: IL6R