Recombinant Human IL-31 Protein

Images

 
There are currently no images for IL-31 Protein (NBP1-99456).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
Lyoph

Order Details

Recombinant Human IL-31 Protein Summary

Description
Recombinant bioactive protein for Human IL-31

Source:E. coli
Amino Acid Sequence:(Q6EBC2) - SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALK SLTSGAQQATT

Details of Functionality
The ED50 was determined by its ability to activate STAT following receptor ligand interaction and found to be <5 ng/ml, corresponding to a specific activity of 200,000 units.
Source
E. coli
Protein/Peptide Type
Biologically Active Protein
Gene
IL31
Purity
>95%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
15.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
Lyophilized from 20 mM phosphate buffer, 150 mM NaCl, pH 7.4
Concentration
Lyoph
Purity
>95%, by SDS-PAGE
Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile H2O to a concentration> 100 ug/ml. This solution can then be diluted into other aqueous buffers.

Alternate Names for Recombinant Human IL-31 Protein

  • IL31
  • IL-31
  • IL-31interleukin-31
  • interleukin 31

Background

IL-31 produced by activated Th2-type T cells, cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is constitutively expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connected with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells. Serum IL-31 level is higher in patients with atopic dermatitis. IL-31 is involved in a broad range of immune- & non-immune cells & possesses potential pleiotropic physiological functions, including regulating hematopoiesis & immune response, causing inflammatory bowel disease, airway hypersensitivity & dermatitis. IL-31 human recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids (24-164 a.a.) and having a molecular mass of 15.8 kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF2769
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
AF662
Species: Mu
Applications: WB, IHC
NB100-68142
Species: Hu
Applications: WB, PEP-ELISA
MAB15041
Species: Hu
Applications: WB, IHC, CyTOF-ready, ICFlow
NBP2-01134
Species: Hu
Applications: WB, IHC, IHC-P
MAB208
Species: Hu
Applications: WB, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
NBP1-32744
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-22471
Species: Hu, Mu, Rt, Mk, Pm
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP
NBP1-90058
Species: Hu
Applications: WB, IHC, IHC-P
NBP1-99456
Species: Hu
Applications: PAGE

Publications for IL-31 Protein (NBP1-99456) (0)

There are no publications for IL-31 Protein (NBP1-99456).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for IL-31 Protein (NBP1-99456) (0)

There are no reviews for IL-31 Protein (NBP1-99456). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for IL-31 Protein (NBP1-99456) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional IL-31 Products

Bioinformatics Tool for IL-31 Protein (NBP1-99456)

Discover related pathways, diseases and genes to IL-31 Protein (NBP1-99456). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-31 Protein (NBP1-99456)

Discover more about diseases related to IL-31 Protein (NBP1-99456).
 

Pathways for IL-31 Protein (NBP1-99456)

View related products by pathway.

PTMs for IL-31 Protein (NBP1-99456)

Learn more about PTMs related to IL-31 Protein (NBP1-99456).

Blogs on IL-31

There are no specific blogs for IL-31, but you can read our latest blog posts.

Customers Who Bought This Also Bought

IL-4 [Unconjugated]
204-IL-010/CF

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Human IL-31 Protein and receive a gift card or discount.

Bioinformatics

Gene Symbol IL31
Entrez