OSMR beta Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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OSMR beta Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse OSM R beta
Glu24-Leu738
Accession # O70458
Specificity
Detects mouse OSM R beta in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
Osmr
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
Publications
Read Publications using
AF662 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OSMR beta Antibody

  • IL-31 receptor subunit beta
  • IL-31R subunit beta
  • IL-31RB
  • IL-31R-beta
  • Interleukin-31 receptor subunit beta
  • MGC150627
  • MGC75127
  • oncostatin M receptor
  • oncostatin-M specific receptor beta subunit
  • oncostatin-M-specific receptor subunit beta
  • OSM R beta
  • OSMR beta
  • OSMR
  • OSMRB
  • OSMRBMGC150626
  • PLCA1

Background

Oncostatin M (OSM) is a member of the IL-6 family of cytokines that share the gp130 as a common signal transducing receptor subunit. Human OSM signals through two types of human OSM receptor complexes: the type I complex comprising the leukemia inhibitory factor receptor beta (LIF R beta ) and gp130, the type II complex made up of OSM receptor beta (OSM R beta ) and gp130. In contrast, mouse OSM signals only through the mouse OSM R beta and gp130 complex. Mouse OSM R beta cDNA encodes a 971 amino acid (aa) residue type I transmembrane protein which contains a 23 aa residue signal peptide, an extracellular domain of 714 aa, a transmembrane domain of 20 aa and a 214 aa cytoplasmic domain. Mouse OSM R beta alone binds mOSM with low-affinity, but forms a high-affinity binding complex in the presence of gp130. Mouse OSM R beta is 55% identical at the amino acid sequence level to human OSM R beta.

  1. Lindberg, R.A. et al. (1998) Mol. Cell. Biol. 18:3357.
  2. Tanaka, M. et al. (1999) Blood 93:804.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for OSMR beta Antibody (AF662)(8)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ELISA Development, Flow Cytometry, IHC, IHC-P, Western Blot.


Filter By Application
ELISA Development
(1)
Flow Cytometry
(1)
IHC
(1)
IHC-P
(1)
Western Blot
(4)
All Applications
Filter By Species
Human
(1)
Mouse
(7)
All Species
Showing Publications 1 - 8 of 8.
Publications using AF662 Applications Species
J Martínez-F, A Prescott, S van Kaster, DL Pedrioli, I McLean, A Moles, T Reinheckel, V Poli, C Watts Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis Nat Commun, 2018;9(1):5343. 2018 [PMID: 30559339] (Western Blot, Mouse) Western Blot Mouse
Carrie M Elks Loss of oncostatin M signaling in adipocytes induces insulin resistance and adipose tissue inflammation in vivo J Biol Chem, 2016;0(0):. 2016 [PMID: 27325693] (Western Blot, Mouse) Western Blot Mouse
Guihard P, Boutet M, Brounais-Le Royer B, Gamblin A, Amiaud J, Renaud A, Berreur M, Redini F, Heymann D, Layrolle P, Blanchard F Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 2015;185(3):765-75. 2015 [PMID: 25559270] (IHC, Mouse) IHC Mouse
Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine, 2014;68(2):101-9. 2014 [PMID: 24767864] (IHC-P, Mouse) IHC-P Mouse
Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y Deficiency of oncostatin M receptor beta (OSMRbeta) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. J Biol Chem, 2014;289(20):13821-37. 2014 [PMID: 24695736] (Western Blot, Mouse) Western Blot Mouse
Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y Lack of oncostatin M receptor beta leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J Biol Chem, 2013;288(30):21861-75. 2013 [PMID: 23760275] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Chollangi, Srinivas, Mather, Timothy, Rodgers, Karla K, Ash, John D A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem, 2012;287(39):32848-59. 2012 [PMID: 22829597] (ELISA Development, Human) ELISA Development Human
Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS. J. Biol. Chem., 2011;286(39):34271-85. 2011 [PMID: 21784845] (Western Blot, Mouse) Western Blot Mouse

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Secondary Antibodies

 

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Other Available Formats

Biotin BAF662

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Bioinformatics

Gene Symbol Osmr
Uniprot