CCM2 Antibody (OTI1E9)

Images

 
Western Blot: CCM2 Antibody (1E9) [NBP2-01134] Analysis of extracts (35ug) from 9 different cell lines by using anti-CCM2 monoclonal antibody.
Immunohistochemistry-Paraffin: CCM2 Antibody (1E9) [NBP2-01134] - Staining of paraffin-embedded Human lymph node tissue using anti-CCM2 mouse monoclonal antibody.
Western Blot: CCM2 Antibody (1E9) [NBP2-01134] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CCM2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ...read more
Immunohistochemistry-Paraffin: CCM2 Antibody (1E9) [NBP2-01134] - Staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-CCM2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: CCM2 Antibody (1E9) [NBP2-01134] - Staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-CCM2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: CCM2 Antibody (1E9) [NBP2-01134] - Staining of paraffin-embedded Carcinoma of Human lung tissue using anti-CCM2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: CCM2 Antibody (1E9) [NBP2-01134] - Staining of paraffin-embedded Human lung tissue using anti-CCM2 mouse monoclonal antibody.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-P
Clone
OTI1E9
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.38 mg/ml

CCM2 Antibody (OTI1E9) Summary

Immunogen
Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CCM2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150
Theoretical MW
48.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
0.38 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCM2 Antibody (OTI1E9)

  • C7orf22OSM
  • cerebral cavernous malformation 2
  • Cerebral cavernous malformations 2 protein
  • chromosome 7 open reading frame 22
  • malcavernin
  • MGC4067
  • MGC4607
  • MGC74868

Background

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-72235AF350
Alexa Fluor 405 NBP2-72235AF405
Alexa Fluor 488 NBP2-72235AF488
Alexa Fluor 532 NBP2-72235AF532
Alexa Fluor 594 NBP2-72235AF594
Alexa Fluor 647 NBP2-72235AF647
Alexa Fluor 700 NBP2-72235AF700
Alexa Fluor 750 NBP2-72235AF750
Biotin NBP2-72235B
DyLight 350 NBP2-72235UV
DyLight 405 NBP2-72235V
DyLight 488 NBP2-72235G
DyLight 550 NBP2-72235R
DyLight 594 NBP2-72235DL594
DyLight 650 NBP2-72235C
DyLight 680 NBP2-72235FR
DyLight 755 NBP2-72235IR
FITC NBP2-72235F
HRP NBP2-72235H
Janelia Fluor 549 NBP2-72235JF549
Janelia Fluor 646 NBP2-72235JF646

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Bioinformatics Tool for CCM2 Antibody (NBP2-01134)

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Bioinformatics

Gene Symbol CCM2
Entrez