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Product Details

Reactivity HuSpecies Glossary
Applications ELISA
Concentration is not relevant for this product. Please see the protocols for proper use of this product.
Suitable Sample Type
Cell culture supernatant, serum, plasma (EDTA, citrate, heparin)

Order Details

IL-31 ELISA Kit Summary

Standard Curve Range
7.8 - 500 pg/mL
1.0 pg/mL
Kit Type

Packaging, Storage & Formulations

Storage of components varies. See protocol for specific instructions.
Concentration is not relevant for this product. Please see the protocols for proper use of this product.


Application Notes
The human IL-31 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human IL-31.

Kit Components

  1. Aluminium pouch(es) with a Microwell Plate coated with polyclonal antibody to human IL-31
  2. Biotin-Conjugate anti-human IL-31 polyclonal antibody
  3. Streptavidin-HRP
  4. Human IL-31 Standard lyophilized, 500 pg/ml upon reconstitution
  5. Sample Diluent
  6. Conjugate Diluent
  7. Calibrator Diluent
  8. Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
  9. Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
  10. Substrate Solution (tetramethyl-benzidine)
  11. Stop Solution (1M Phosphoric acid)
  12. Adhesive Films

Reactivity Notes



Colored dyes for optional use with this kit are available and will be provided free of charge upon request. Please refer to catalog number NBP2-41404.

Alternate Names for IL-31 ELISA Kit

  • IL31
  • IL-31interleukin-31
  • interleukin 31


IL-31 is a 24kD and 164 AA alpha-helical protein with a four-helix bundle structure, preferentially produced by CD 4+ type 2 helper T cells. IL-31 is closely related to the IL-6 type cytokines such as oncostatin M, Leukemia inhibitory factor and cardiotrophin 1. IL-31 signals via binding to a heterodimeric complex that is composed of IL-31 receptor A (IL-31RA) that is highly homologous with the gp 30-like receptor and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes, in epithelial cells, and keratinocytes respectively. On target cells IL-31 binding can induce activation of the JAK/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles including regulation of hematopoiesis and immune response. When overexpressed in transgenic mice, IL-31 induces severe pruritus resembling eczema in humans. Serum IL-31 was previously found overexpressed in adults with atopic dermatitis (AD). Serum measurement of IL-31 in paediatric atopic dermatitis revealed that elevated levels correlate with severity scoring. Activated effector T cells are recruited to the skin by chemokines and cell adhesion molecules. These components in the local microenvironment prolong T cell survival and contribute to the chronicity of these diseases. IL-31 is associated with the promotion of allergic and chronic inflammatory conditions such as dermatitis, pruritus, airway hypersensititvity and inflammatory bowel disease.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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Contact Information

Product PDFs


Gene Symbol IL31

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