IL-22 Antibody

Immunohistochemistry: IL-22 Antibody [NB100-737] - Rabbit antibody to N-terminus of mouse IL-22 on mouse spleen.

Product Discontinued

IL-22 Antibody Summary

• Immunogen: Synthetic peptide: CKLEVSNFQQPYIVNRTFMLAKEASLAD, corresponding to amino acids 40-67 of Mouse IL22 precursor.
• Localization: Secreted
• Specificity: The peptide sequence is <50% identical to other interleukins in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: IL22
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100000
  • Immunohistochemistry 1:500
  • Immunohistochemistry-Paraffin 1:500

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4, 0.14M NaCl and 1.0 mg/ml BSA
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for IL-22 Antibody

• Cytokine Zcyto18
• IL-10-related T-cell-derived inducible factor
• IL22
• IL-22
• IL-D110
• IL-TIF
• ILTIFIL-10-related T-cell-derived-inducible factor
• IL-TIFMGC79382
• interleukin 22
• interleukin-22
• MGC79384
• TIFa
• TIFIL-23
• zcyto18

Background

IL22 is a cytokine structurally related to IL10 and is upregulated in activated T cells. IL22 signals through a receptor complex that includes CRF2-4 and a new member of the class II cytokine receptor family (also known as the interferon receptor family), IL22R. CRF2-4 has previously been demonstrated to be a functional component of the IL-10 signaling complex. IL22 is able to suppress IL4 production; this may have therapeutic potential, particularly in the treatment of asthma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL-22 Antibody (NB100-737)(8)

Publications using NB100-737

• Li Y, Li J, Jia D et al. The Microbial Tryptophan Metabolite Contributes to the Remission of Salmonella typhimurium Infection in Mice Journal of immunology (Baltimore, Md. : 1950) 2023-11-29 [PMID: 38019127]
• Cheng Y, Li J, Zhang X et al. Protective Effect of Qingchang Wenzhong Decoction on Colitis and Colitis-Related Carcinogenesis by Regulating Inflammation and Intestinal Fibrosis Journal of inflammation research 2023-04-07 [PMID: 37056910] (IHC-P, Mouse)
• de Brito RJVC, do Carmo RF, Silva BMS et al. Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages Cytokine 2021-12-15 [PMID: 34920229] (IF/IHC, Human)
• Kang L, Zhang X, Ji L et al. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens J. Exp. Med. 2020-04-06 [PMID: 31944217]
• Roth S, Spalinger MR, Gottier C et al. Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. PLoS ONE. 2016-05-07 [PMID: 27152519] (IHC-P, Human)
• Ciccia F, Rizzo A, Alessandro R et al. Activated IL-22 pathway occurs in the muscle tissues of patients with polymyositis or dermatomyositis and is correlated with disease activity. Rheumatology (Oxford) 2014-03-05 [PMID: 24599919] (IHC-P, Human)
• Ciccia F, Accardo-Palumbo A, Alessandro R, Rizzo A, Principe S, Peralta S, Raiata F, Giardina A, De Leo G, Triolo G. Interleukin-22 and IL-22-producing NKp44(+) NK cells in the subclinical gut inflammation of patients with ankylosing spondylitis. Arthritis Rheum. 2011-12-27 [PMID: 22213179] (IF/IHC, Human)
• Ciccia F, Guggino G, Rizzo A et al. Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren's syndrome. Ann Rheum Dis 2012-02-01 [PMID: 21979002] (Human)

Bioinformatics

• Gene Symbol: IL22
• Entrez:
  • 50929(Mouse)