IL-22 Antibody

Product Discontinued

IL-22 Antibody Summary

• Immunogen: Synthetic peptide CRLDKSNFQQPYITNRTFMLAKEASLAD corresponding to N-terminus of human IL-22
• Localization: Secreted
• Specificity: The peptide sequence is <50% identical to other interleukins in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: IL22
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:50000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:250

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4 and 0.14M NaCl, BSA.
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for IL-22 Antibody

• Cytokine Zcyto18
• IL-10-related T-cell-derived inducible factor
• IL22
• IL-22
• IL-D110
• IL-TIF
• ILTIFIL-10-related T-cell-derived-inducible factor
• IL-TIFMGC79382
• interleukin 22
• interleukin-22
• MGC79384
• TIFa
• TIFIL-23
• zcyto18

Background

IL22 is a cytokine structurally related to IL10 and was originally identified in the mouse as a gene induced by IL9 in T cells and mast cells. IL22 is upregulated in activated T cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL-22 Antibody (NB100-733)(5)

Publications using NB100-733

• Morelli M, Scarponi C, Madonna S, Albanesi C Experimental Methods for the Immunological Characterization of Paradoxical Psoriasis Reactions Induced by TNF-alpha Biologics Methods Mol Biol 2020-11-14 [PMID: 33185874] (IF/IHC)
• Piro MC, Ventura A, Smirnov A et al. Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin Int J Mol Sci 2020-02-25 [PMID: 32106600] (IHC-P, IF/IHC, Mouse)
• Fania L, Morelli M, Scarponi C et al. Paradoxical psoriasis induced by TNF-alpha blockade shows immunological features typical of the early phase of psoriasis development J Pathol Clin Res 2019-10-02 [PMID: 31577850] (IHC-P, Human)
• Pennino D, Bhavsar PK, Effner R et al. IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients J Allergy Clin Immunol 2012-11-19 [PMID: 23174657] (IF/IHC, Human)
• Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H. The promotional effect of IL-22 on mineralization activity of periodontal ligament cells. Cytokine. 2012-04-24 [PMID: 22537848] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: IL22
• Entrez:
  • 50616(Human)
• Uniprot:
  • Q9GZX6()