IL-2 Antibody (5334) [Unconjugated]

Images

 
IL‑2 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) treated with calcium ionomycin and PMA using Mouse Anti-Human IL‑2 Monoclonal Antibody (Catalog # MAB202) at 8 µg/mL for ...read more
Recombinant Human IL‑2 (Catalog # 202-IL) stimulates proliferation in the CTLL‑2 mouse cytotoxic T cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL‑2 (2 ng/mL) is ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications B/N, CyTOF-ready, Flow, ICC/IF
Clone
5334
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

IL-2 Antibody (5334) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human IL‑2
Ala21-Thr153
Accession # NP_000577
Specificity
Detects human IL-2 in direct ELISAs. Does not cross-react with recombinant IL-2 from mouse, rat, pig, or cotton rat.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL2
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunocytochemistry 8-25 ug/mL
  • Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells
  • Neutralization 0.015-0.03 ug/mL
Publications
Read Publications using
MAB202 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-2 Antibody (5334) [Unconjugated]

  • aldesleukin
  • IL2
  • IL-2
  • IL-2lymphokine
  • interleukin 2
  • interleukin-2
  • involved in regulation of T-cell clonal expansion
  • T cell growth factor
  • T-cell growth factor
  • TCGF

Background

Interleukin 2 (IL-2) is a cytokine that stimulates the growth and differentiation of B cells, T cells, NK cells, and monocyte/macrophages. It functions through the heterotrimeric IL-2 receptor comprising alpha, beta, and gamma chains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-2 Antibody (MAB202)(12)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Bioassay, Flow, Neut.


Filter By Application
Bioassay
(2)
Flow
(4)
Neut
(6)
All Applications
Filter By Species
Human
(12)
All Species
Showing Publications 1 - 10 of 12. Show All 12 Publications.
Publications using MAB202 Applications Species
T Carmenate, Y Ortíz, M Enamorado, K García-Mar, J Avellanet, E Moreno, L Graça, K León Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells J. Immunol., 2018;0(0):. 2018 [PMID: 29618524] (Bioassay, Human) Bioassay Human
S Revu, J Wu, M Henkel, N Rittenhous, A Menk, GM Delgoffe, AC Poholek, MJ McGeachy IL-23 and IL-1? Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation Cell Rep, 2018;22(10):2642-2653. 2018 [PMID: 29514093] (Neut,, Human) Neut Human
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling Sci Rep, 2016;6(0):32320. 2016 [PMID: 27586092] (Flow,, Human) Flow Human
Activin A programs the differentiation of human TFH cells Nat Immunol, 2016;17(8):976-84. 2016 [PMID: 27376469] (Bioassay,, Human) Bioassay Human
Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, Azimi N, Tagaya Y Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. J Biol Chem, 2015;290(37):22338-51. 2015 [PMID: 26183780] (Neut,, Human) Neut Human
Kim, Dae Won, Zloza, Andrew, Broucek, Joseph, Schenkel, Jason M, Ruby, Carl, Samaha, Georges, Kaufman, Howard L Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med, 2014;12(0):113. 2014 [PMID: 24885155] (Neut,, Human) Neut Human
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation. Blood, 2012;119(26):6268-77. 2012 [PMID: 22577174] (Neut,, Human) Neut Human
Hutnick NA, Carnathan D, Demers K, Makedonas G, Ertl HC, Betts MR Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive. Vaccine, 2010;28(8):1932-41. 2010 [PMID: 20188249] (Flow,, Human) Flow Human
Withers DR, Fiorini C, Fischer RT, Ettinger R, Lipsky PE, Grammer AC T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue. Blood, 2007;109(11):4856-64. 2007 [PMID: 17299094] (Neut,, Human) Neut Human
Karenko L, Hahtola S, Paivinen S, Karhu R, Syrja S, Kahkonen M, Nedoszytko B, Kytölä S, Zhou Y, Blazevic V, Pesonen M, Nevala H, Nupponen N, Sihto H, Krebs I, Poustka A, Roszkiewicz J, Saksela K, Peterson P, Visakorpi T, Ranki A Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res., 2005;65(18):8101-10. 2005 [PMID: 16166283] (Flow,, Human) Flow Human
Show All 12 Publications.

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Blogs on IL-2.

The role of HIF-2 alpha in the progression and therapy of clear cell renal cell carcinoma
HIF-2 alpha, also known as hypoxia-inducible factor 2, endothelial PAS domain protein-1, and member of PAS superfamily 2 is part of the HIF family of proteins.  The HIF family is composed of HIF-1, HIF-2 and HIF-3, where HIF-2 is a dimeric protein...  Read full blog post.

iNOS: The Nitric Oxide Boss
Nitric oxide (NO) is an inorganic, gaseous, and reactive free radical that acts as a biologic mediator in processes such as neurotransmission, vasorelaxation, and cytotoxicity. In addition, it has antimicrobial and anti-tumoral activities. NO producti...  Read full blog post.

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Bioinformatics

Gene Symbol IL2
Uniprot