IL-17RA/IL-17R Antibody (105828) [Alexa Fluor® 647]

• Reactivity: Mu
• Applications: WB
• Clone: 105828
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 647

IL-17RA/IL-17R Antibody (105828) [Alexa Fluor® 647] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL‑17 RA/IL‑17 R
  Extracellular domain
  Accession # Q60943
• Specificity: Detects mouse IL‑17 RA/IL‑17 R in direct ELISAs and Western blots. Shows 50-100% cross‑reactivity with recombinant human IL-17 RA/IL-17 R and no cross‑reactivity with recombinant mouse IL-17B R.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-17RA/IL-17R Antibody (105828) [Alexa Fluor® 647]

• CD217 antigen
• CD217
• Cdw217
• CDw217interleukin 17 receptor
• hIL-17R
• IL-17 R
• IL-17 RA
• IL-17 receptor A
• IL17RA
• IL-17RA
• IL-17RAMGC10262
• IL17Rinterleukin-17 receptor A
• interleukin 17 receptor A

Background

IL-17 R, also known as IL-17 RA, is a widely expressed 120 kDa glycosylated type I protein that plays a central role in inflammatory responses. IL-17 R associates with IL-17 RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17 R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, human IL-17 R shares 72% aa sequence identity with mouse and rat IL-17 R.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.