IL-17E/IL-25 Antibody (207702) [Allophycocyanin]

• Reactivity: Mu
• Applications: CyTOF-ready, ELISA, ELISA(Cap), ELISA(Det), Flow
• Clone: 207702
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Allophycocyanin

IL-17E/IL-25 Antibody (207702) [Allophycocyanin] Summary

• Immunogen: E. coli-derived recombinant mouse IL‑17E/IL-25
  Val17-Ala169
  Accession # NP_542767
• Specificity: Detects mouse IL‑17E/IL-25 in ELISAs. In ELISAs, no cross-reactivity with recombinant human IL‑17E, recombinant mouse (rm) IL‑17,
  rmIL‑17B, C, D, or F is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: IL25
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Intracellular Staining by Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for IL-17E/IL-25 Antibody (207702) [Allophycocyanin]

• IL17E
• IL-17E
• IL25
• IL-25
• interleukin 25
• Interleukin-17E
• interleukin-25

Background

Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E (2). IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al (6) and Lee, et al. (2) and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IL25