IL-1 RI Antibody (JAMA-147)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, IP
Clone
JAMA-147
Clonality
Monoclonal
Host
Armenian Hamster
Conjugate
Unconjugated
Concentration
1.0 mg/ml

IL-1 RI Antibody (JAMA-147) Summary

Immunogen
Extracellular domain of murine IL-1R.
Specificity
NB100-65865 recognizes murine CD121a, which is the 80kD type I interleukin-1 receptor. CD121a is weakly expressed on most cells and tissues including T lymphocytes, thymocytes, epithelial cells and dendritic cells, with stronger expression reported on fibroblasts. The ligands for CD121a are the interleukin-1 (IL-1) family members; IL-1 alpha; IL-1 beta and IL-1 receptor antagonist. IL-1 is a mediator of inflammation and can elicit a variety of other biological responses through binding to CD121a. Clone JAMA-147 has been reported to block IL-1 dependent cellular responses. (1).
Isotype
IgG
Clonality
Monoclonal
Host
Armenian Hamster
Gene
IL1R1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:25-1:100
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

Reacts with Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for IL-1 RI Antibody (JAMA-147)

  • CD121 antigen-like family member A
  • CD121a antigen
  • CD121a
  • IL-1 RI
  • IL1R
  • IL1R1
  • IL1RI
  • IL-1RI
  • IL1RT1
  • IL-1RT1
  • IL-1RT-1
  • Interleukin 1 Receptor 1
  • interleukin 1 receptor, type I
  • interleukin receptor 1
  • interleukin-1 receptor type 1
  • p80

Background

IL1 binds antigen CD121a, which is a transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. CD121a binds the mature forms of IL1 alpha, IL1 beta, and IL1 Ra proteins. High affinity binding and signaling by the type I IL1 receptor requires CD121a and the accessory protein, IL1 R AcP, which does not bind IL1 alone, but forms a dimer capable of binding IL1. Interleukin 1 (IL1), which has a role as a mediator in inflammation, consists of 2 separate but related proteins, IL1 alpha and IL1 beta. Cell surface receptors for the 2 forms of IL1 are identical. IL1R Type I contains a single membrane spanning segment, a large cytoplasmic region, and an extracellular, IL1 binding portion composed of 3 immunoglobulin like domains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-65865AF405
Alexa Fluor 488 Labeled NB100-65865AF488
Alexa Fluor 647 Labeled NB100-65865AF647
Alexa Fluor 700 Labeled NB100-65865AF700
Allophycocyanin Labeled NB100-65865APC
DyLight 350 Labeled NB100-65865UV
DyLight 405 Labeled NB100-65865V
DyLight 488 Labeled NB100-65865G
DyLight 680 Labeled NB100-65865FR
DyLight 755 Labeled NB100-65865IR
PE Labeled NB100-65865PE
PerCP Labeled NB100-65865PCP

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Bioinformatics

Gene Symbol IL1R1
Entrez
Uniprot