IL-1 RI Antibody (JAMA-147)


There are currently no images for IL-1 RI Antibody (NB100-65865).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity MuSpecies Glossary
Applications B/N, Flow, IP
Armenian Hamster
1.0 mg/ml

IL-1 RI Antibody (JAMA-147) Summary

Extracellular domain of murine IL-1R.
NB100-65865 recognizes murine CD121a, which is the 80kD type I interleukin-1 receptor. CD121a is weakly expressed on most cells and tissues including T lymphocytes, thymocytes, epithelial cells and dendritic cells, with stronger expression reported on fibroblasts. The ligands for CD121a are the interleukin-1 (IL-1) family members; IL-1 alpha; IL-1 beta and IL-1 receptor antagonist. IL-1 is a mediator of inflammation and can elicit a variety of other biological responses through binding to CD121a. Clone JAMA-147 has been reported to block IL-1 dependent cellular responses. (1).
Armenian Hamster
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Blocking/Neutralizing
  • Flow Cytometry 1:25-1:100
  • Immunoprecipitation 1:10-1:500
Application Notes
Measured by its ability to neutralize IL-1 alpha /IL-1F1-induced proliferation in the D10.G4.1 mouse helper T cell line. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The Neutralization Dose (ND50) is typically 0.05-0.15 ug/mL in the presence of 50 pg/mL Recombinant Mouse IL-1 alpha /IL-1F1 and 1.25 ug/mL concanavalin A.

Reactivity Notes

Reacts with Mouse.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4)
0.09% Sodium Azide
1.0 mg/ml
Protein G purified

Alternate Names for IL-1 RI Antibody (JAMA-147)

  • CD121 antigen-like family member A
  • CD121a antigen
  • CD121a
  • IL-1 RI
  • IL1R
  • IL1R1
  • IL1RI
  • IL-1RI
  • IL1RT1
  • IL-1RT1
  • IL-1RT-1
  • Interleukin 1 Receptor 1
  • interleukin 1 receptor, type I
  • interleukin receptor 1
  • interleukin-1 receptor type 1
  • p80


IL1 binds antigen CD121a, which is a transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. CD121a binds the mature forms of IL1 alpha, IL1 beta, and IL1 Ra proteins. High affinity binding and signaling by the type I IL1 receptor requires CD121a and the accessory protein, IL1 R AcP, which does not bind IL1 alone, but forms a dimer capable of binding IL1. Interleukin 1 (IL1), which has a role as a mediator in inflammation, consists of 2 separate but related proteins, IL1 alpha and IL1 beta. Cell surface receptors for the 2 forms of IL1 are identical. IL1R Type I contains a single membrane spanning segment, a large cytoplasmic region, and an extracellular, IL1 binding portion composed of 3 immunoglobulin like domains.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt, Rb
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IP
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, Flow-IC
Species: Hu, Mu, Rt, Bv, Ca, Ch, Xp
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, ELISA, ICC/IF, IP
Species: Hu, Mu, Rt
Applications: WB, ICC

Publications for IL-1 RI Antibody (NB100-65865) (0)

There are no publications for IL-1 RI Antibody (NB100-65865).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for IL-1 RI Antibody (NB100-65865) (0)

There are no reviews for IL-1 RI Antibody (NB100-65865). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for IL-1 RI Antibody (NB100-65865) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-65865AF405
Alexa Fluor 488 Labeled NB100-65865AF488
Alexa Fluor 647 Labeled NB100-65865AF647
Alexa Fluor 700 Labeled NB100-65865AF700
Allophycocyanin Labeled NB100-65865APC
DyLight 350 Labeled NB100-65865UV
DyLight 405 Labeled NB100-65865V
DyLight 488 Labeled NB100-65865G
DyLight 680 Labeled NB100-65865FR
DyLight 755 Labeled NB100-65865IR
PE Labeled NB100-65865PE
PerCP Labeled NB100-65865PCP

Additional IL-1 RI Products

Bioinformatics Tool for IL-1 RI Antibody (NB100-65865)

Discover related pathways, diseases and genes to IL-1 RI Antibody (NB100-65865). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-1 RI Antibody (NB100-65865)

Discover more about diseases related to IL-1 RI Antibody (NB100-65865).

Pathways for IL-1 RI Antibody (NB100-65865)

View related products by pathway.

PTMs for IL-1 RI Antibody (NB100-65865)

Learn more about PTMs related to IL-1 RI Antibody (NB100-65865).

Research Areas for IL-1 RI Antibody (NB100-65865)

Find related products by research area.

Blogs on IL-1 RI

There are no specific blogs for IL-1 RI, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our IL-1 RI Antibody (JAMA-147) and receive a gift card or discount.


Gene Symbol IL1R1