IkB-beta [p Ser23] Antibody - BSA Free

Immunohistochemistry: IkB-beta [p Ser23] Antibody [NBP2-54761] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-B [P-Ser23].

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

IkB-beta [p Ser23] Antibody - BSA Free Summary

• Immunogen: IkB-beta (Phospho-Ser23) antibody was raised against a peptide sequence around phosphorylation site of serine 23 (L-G-S (p) -L-G) derived from Human IkappaB-b
• Modification: p Ser23
• Specificity: This antibody detects endogenous level of IkB-beta; only when phosphorylated at serine 23.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NFKBIB
• Purity: Epitope affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:100
• Theoretical MW: 48 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 degrees C. Avoid freeze/thaw cycles.
• Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Epitope affinity purified

Alternate Names for IkB-beta [p Ser23] Antibody - BSA Free

• beta
• IkappaBbeta
• I-kappa-B-beta
• ikB-B
• IkBbeta
• IkB-beta
• IKBBikB-beta
• NF-kappa-B inhibitor beta
• NF-kappa-BIB
• NFKBIB
• nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
• Thyroid receptor-interacting protein 9
• TR-interacting protein 9
• TRIP-9
• TRIP9ikappaBbeta

Background

Inhibits NF-k-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-k-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NFKBIB